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dc.contributor.authorHernando, Ainara
dc.contributor.authorMateo Alesanco, Estíbaliz
dc.contributor.authorOrtega Riveros, Marcelo
dc.contributor.authorPinta, Iker de la
dc.contributor.authorQuindós Andrés, Guillermo
dc.contributor.authorEraso Barrio, Elena
dc.date.accessioned2020-06-30T10:44:59Z
dc.date.available2020-06-30T10:44:59Z
dc.date.issued2019
dc.identifier.citationEkaia 36 : 175-190 (2019)
dc.identifier.issn0214-9001
dc.identifier.urihttp://hdl.handle.net/10810/44737
dc.description.abstractCandidiasis is a mycotic infection caused by species of Candida genus. Candida albicans is the major aetiological agent, although other species of Candida, such as Candida glabrata, are considered emerging causes of this disease. The species, Candida bracarensis and Candida nivariensis, are phylogenetically similar to Candida glabrata and can be correctly differentiated by molecular techniques. These changes in the aetiology have serious implications for diagnosis, treatment and prognosis; considering that yeast pathogenesis or susceptibilities to current antifungal drugs may be different. Invertebrate models, such as the nematode Caenorhabditis elegans and the lepidopter Galleria mellonella, are an attractive alternative for the study of fungal pathogenesis and antifungal therapy. The aim of this research study was to evaluate the usefulness of these two non-convetional model to assess the in vivo virulence of the phylogenetically close-related species, Candida glabrata, Candida bracarensis and Candida nivariensis.; Kandidiasia Candida generoko espezieek eragindako infekzio mikotikoa da. Candida albicans agente etiologiko nagusia da baina gero eta gehiagotan Candida generoko beste espezie batzuk agertzen ari dira kandidiasiaren eragile bezala eta, hauen artean, Candida glabrata espeziea. Espezie honekin lotuta beste bi espezie daude, Candida bracarensis eta Candida nivariensis, teknika molekularrek ondo desberdindu ditzaketenak. Aldaketa etiologiko hauek ondorio larriak izan ditzakete kandidiasiaren diagnostikoan, tratamenduan edota pronostikoan, besteak beste, bere patogenia edo antifungikoekiko sentikortasuna oso desberdina izan daitezkeelako. Ordezko eredu esperimentalek erabiliz mikroorganismoek eragindako gaixotasunen patogenia eta terapia ezagutzeko ezinbesteko aukera ematen dizkigute, eta hauen artean, Caenorhabditis elegans nematodoa eta Galleria mellonella lepidopteroa ditugu. Ikerketa lan honetan konbentzionalak ez diren bi animalia eredu hauen erabilgarritasuna ebaluatu nahi izan da Candida glabrata, Candida bracarensis eta Candida nivariensis harreman filogenetiko estua duten hiru espezie hauen birulentzia in vivo aztertzeko.
dc.language.isoeus
dc.publisherServicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.titleGalleria mellonella insektua eta Caenorhabditis elegans nematodoa, infekzio eredu boteretsuak Candida glabrata eta erlazionatutako espezieen birulentzia ikertzeko.
dc.typeinfo:eu-repo/semantics/article
dc.rights.holder© 2019 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
dc.identifier.doi10.1387/ekaia.20323


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© 2019 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as © 2019 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International