Examinar IKERKUNTZA por departamento (eus.) "Farmakologia"
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Cannabinoid modulation of the cortical information processing through the basal ganglia circuits in physiological and hypodopaminergic states
(2021-07-23)The basal ganglia (BG) are a network of subcortical nuclei that classically have been considered to be involved in motor behaviours, with mounting evidence in the last decades indicating that they are also involved in ... -
Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion.
(ACS, 2022-08-04)The endocannabinoid system modulates learning, memory, and neuroinflammatory processes, playing a key role in neurodegeneration, including Alzheimer’s disease (AD). Previous results in a rat lesion model of AD showed ... -
Cannabinoid receptors in animal models of cognitive impairment.
(2024-03-15)The endocannabinoid system (eCB) plays a crucial role in various physiological processes including fear responses, learning and memory. This system comprises cannabinoid receptors, endogenous ligands and enzymes, and its ... -
Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
(eLife Sciences, 2022-10)Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ... -
Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients
(Wiley, 2022-11)Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved in psychosis and, like ... -
Caracterización de las proteínas del complejo SNARE en esquizofrenia y su tratamiento
(2015-11-19)La esquizofrenia es una enfermedad de base biológica cuyo sustrato es poco conocido. A partir de un estudio de proteómica comparativa realizados en cerebro postmortem de individuos con esquizofrenia y individuos control ... -
CB1 and LPA(1) Receptors Relationship in the Mouse Central Nervous System
(Frontiers Media, 2019-09-19)Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, ... -
Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping Out of the Striatum
(MDPI, 2019-08-29)The basal ganglia (BG) are a collection of interconnected subcortical nuclei that participate in a great variety of functions, ranging from motor programming and execution to procedural learning, cognition, and emotions. ... -
Cellular neurochemical characterization and subcellular localization of Phospholipase C-β1 in rat brain
(Elsevier, 2012-10-11)The present study describes a complete and detailed neuroanatomical distribution map of the phospholipase C beta1 (PLCβ1) isoform along the adult rat neuraxis, and defines the phenotype of cells expressing PLCβ1, along ... -
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
(Frontiers Media, 2020-10-14)The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ... -
Characterization of a double-hit mouse model of schizophrenia. Focus on inflammatory and epigenetic processes, pharmacological modulation and sex bias
(2023-02-17)Los déficits cognitivos de la esquizofrenia son un síntoma central, son indicadores del pronóstico de la enfermedad y son resistentes a los tratamientos actuales. Se sospecha que los antipsicóticos atípicos podrían empeorar ... -
Characterization of an animal model of cognitive impairment associated with schizophrenia. Effets of alpha2-adrenoceptor compounds.
(2019-12-02)Schizophrenia is a multi multifaceted, heterogeneous, chronic and debilitating disorder triggered by a series of interacting genetic, developmental and environmental factors. Cognitive impairment is considered a core feature ... -
Characterization of buspirone effect on output basal ganglia nuclei in 6-hydroxydopamine lesioned rats with and without long-term levodopa treatment.
(2020-05-22)La enfermad de Párkinson es un trastorno neurodegenerativo en el que varios sistemas de neurotransmisión se ven afectados. En los últimos años, numerosas evidencias clínicas y experimentales han demostrado el papel del ... -
Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
(Springer, 2021-08)Background: Alterations of dopamine D-1 (D1R) and D-2 receptor (D2R) are proposed in schizophrenia but brain neuroimaging and postmortem studies have shown controversial results in relation to D1R and D2R density. Besides, ... -
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Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
(Dove Medical Press, 2014)Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared ... -
Constitutive activity and drug functional selectivity of 5-HT2A receptors in post-mortem brain of subjects with schizophrenia
(2022-07-12)La esquizofrenia es una enfermedad mental crónica e incapacitante de etiología aún desconocida. El receptor 2A de serotonina (5-HT2AR) es a la vez diana de compuestos alucinógenos y de antipsicóticos atípicos. Los estudios ... -
Current Techniques for Investigating the Brain Extracellular Space
(Frontiers Media, 2020-10-14)The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions ... -
Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain
(Biomed Central, 2014-07-29)Background: An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the central nervous system (CNS) has been suggested to be ... -
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
(Nature Publishing, 2018-06-11)Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement ...