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Autophagy-related proteins: in vitro studies of protein-lipid interactions modulating autophagosome elongation
(2016-03-18)
La autofagia es un proceso catabólico implicado en el desarrollo de un amplio espectro de enfermedades humanas. Se caracteriza por la formación de una estructura de doble membrana denominada autofagosoma, la cual incorpora ...
Variants in vincristine pharmacodynamic genes involved in neurotoxicity at induction phase in the therapy of pediatric acute lymphoblastic leukemia
(Springer, 2019-02-06)
Vincristine is an important drug of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early ...
Lack of association between deficient mismatch repair expression and outcome in endometrial carcinomas of the endometrioid type
(Elsevier, 2014-05-09)
Objective: Endometrial carcinomas of the endometrioid type (EEC) are associated with a good prognosis. However, about 20% of them recur and new prognostic markers are needed. Microsatellite instability (MSI), associated ...
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease
(Elsevier, 2013-12-27)
[EN] Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the omega-3 polyunsaturated fatty acid ...
Changes in Membrane Organization upon Spontaneous Insertion of 2‑Hydroxylated Unsaturated Fatty Acids in the Lipid Bilayer
(American Chemical Society, 2014-02-03)
Recent research regarding 2-hydroxylated fatty acids (2OHFAs) showed clear evidence of their benefits in the treatment of cancer, inflammation, and neurodegenerative disorders such as Alzheimer’s disease. Monolayer ...
Social Equity Matters in Payments for Ecosystem Services
(Oxford University Press, 2014-09-30)
Although conservation efforts have sometimes succeeded in meeting environmental goals at the expense of equity considerations, the changing context of conservation and a growing body of evidence increasingly suggest that ...
Mechanism for ESCPE-1 mediated membrane remodelling and cargo selection in endosomal
(2020-10-02)
El reciclaje de proteínas es fundamental para mantener la homeostasis celular. Este trabajo se enfoca en el reciclaje de proteínas que llegan a los endosomas. Allí, las proteínas transmembrana (receptores) son recicladas ...
A methodology to determine reliability issues in automotive SiC power modules combining 1D and 3D thermal simulations under driving cycle profiles
(Elsevier, 2019-09-12)
Current environmental concerns and fuel scarcity are leading to the progressive introduction of Electric Vehicles (EV) in the global fleet vehicle population. This requires significant design and research efforts from ...
Structural and magnetic properties of Nd-Fe-Mo-(N) melt-spun ribbons with ThMn12 structure
(Elsevier, 2020-06-03)
The influence of quenching rate and nitrogenation in melt-spun Nd1.2Fe10.6Mo1.4 has been investigated in
terms of microstructure, phase formation and magnetic properties. Increasing the quenching rate leads
to smaller ...
Structural and magnetic properties of hexagonal Fe3Sn prepared by non-equilibrium techniques
(Elsevier, 2018-07-29)
We report a thorough structural and magnetic study of Fe3Sn produced either by solid state reaction or by mechanical alloying in order to figure out which of the two techniques is most suitable for obtaining the purest ...