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The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
(2015-05-27)
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular,
height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research.
However, ...
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
(Elsevier, 2016-07-13)
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the ...
Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α´-Hydroxy Enones as Key Enoate Equivalent
(ACS, 2014-11-25)
Catalytic and asymmetric Michael reactions constitute very powerful tools for the construction of new C–C bonds in synthesis, but most of the reports claiming high selectivity are limited to some specific combinations of ...
Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes
(Wiley-VCH, 2019-07-18)
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and ...
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis
(Wiley, 2019-03-21)
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts ...
Asymmetric a-functionalization of cyclid ketones promoted by bronsted base/H-bond catalysts.
(2019-11-18)
En esta tesis doctoral se han desarrollado nuevas metodologías para la -funcionalización regio- y estereoselectiva de cetonas cíclicas. Para ello se han empleado catalizadores con carácter bifuncional base de Brønsted/dador ...
Asymmetric a-functionatlization of barbituric acids via bronsted base catalysis.
(2019-01-18)
El objetivo de esta tesis ha sido lograr la ¿-desimetrización de amidas por medio de la organocatálisis.Este estudio ha sido enfocado a dos subconjuntos de amidas: derivados del ácido barbitúrico y ¿-iminoamidas, debido a ...
Síntesis enantio- y diastereocontrolada de aminas y alcoholes propargílicos mediante reacciones de Mannich y aldólica organocatalíticas
(2015-12-16)
Las unidades estructurales que contienen aminas o alcoholes propargílicos están presentes en muchos compuestos biológicamente activos y/o son importantes precursores para su síntesis. Por ello, han sido notables los esfuerzos ...
α-Hydroxy Ketones as Masked Ester Donors in Brønsted Base-Catalyzed Conjugate Additions to Nitroalkenes
(ChemPubSoc Europe, 2018-02-15)
Organocatalytic α-functionalization of carbonyl compounds: chemo-, regio- and stereoselectivity.
(2018-05-07)
The aim of this thesis has been the development of new synthetic procedures for the asymmetric formation of carbonyl componenets bearing a stereocenter at C¿. Covered topics include (i) the particular case of the use of ...