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Novel nanostructured lipid carriers based on Ω-3 polyunsaturated fatty acids and TAT peptide for neurodegenerative disease treatment
(2020-12-14)
Neurodegenerative diseases (NDs) are an accelerating global problem, but we still lack routes to develop effective therapeutics. In this quest, it is crucial to identify novel drug candidates or drug carriers, which cross ...
Characterization of edible oils main and minor components and study of their evolution during oxidation, nixtamalization and in vitro digestion processes by non-conventional tecniques DI-SPME-GC/MS and1H NMR spectroscopy
(2020-07-27)
En la presente tesis doctoral, por un lado, se abordó el estudio de la caracterización de aceites vegetales de diferente origen botánico, prestando atención a su composición en componentes minoritarios mediante el empleo ...
Impact of Augmented Renal Clearance in Critically Ill Patients: Population Pharmacokinetics of Levetiracetam and Dosing Evaluation
(2022-06-27)
Introduction: Augmented renal clearance (ARC) is a phenomenon recently identified in critically ill patients.ARC has the potential to influence the pharmacokinetic profile of any drug that is renally cleared andknown to ...
Study of the In Vitro Digestion of Olive Oil Enriched or Not with Antioxidant Phenolic Compounds. Relationships between Bioaccessibility of Main Components of Different Oils and Their Composition
(MDPI, 2020-06-20)
The changes provoked by in vitro digestion in the lipids of olive oil enriched or not with different phenolic compounds were studied by proton nuclear magnetic resonance (1H NMR) and solid phase microextraction followed ...
A Global Study by 1H NMR Spectroscopy and SPME-GC/MS of the in Vitro Digestion of Virgin Flaxseed Oil Enriched or not with Mono-, Di- or Tri-Phenolic Derivatives. Antioxidant Efficiency of These Compounds
(MDPI, 2020-04-15)
The effect of enriching virgin flaxseed oil with dodecyl gallate, hydroxytyrosol acetate or gamma-tocopherol on its in vitro digestion is studied by means of proton nuclear magnetic resonance and solid phase microextraction ...
Key Aspects in Nutritional Management of COVID-19 Patients
(MDPI, 2020-08-10)
This review deals with the relationship among nutrition, the immune system, and coronavirus disease 2019 (COVID-19). The influence of nutrients and bioactive molecules present in foodstuffs on immune system activity, the ...
The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
(MDPI, 2021-06-03)
Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to establish rational dosage regimens of antimicrobial agents in human and veterinary medicine. Actually, PK/PD studies are included in the ...
Desarrollo de un protocolo de actuación para la asistencia a pacientes con discapacidad visual en la farmacia comunitaria
(2020)
Introducción. La farmacia asistencial es la principal actividad de los y las farmacéuticas, jugando un papel fundamental en la optimización del uso de los medicamentos y el acceso a los mismos. Las personas con algún tipo ...
Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study
(BMC, 2022-04)
[EN] Background Levetiracetam pharmacokinetics is extensively altered in critically ill patients with augmented renal clearance (ARC). Consequently, the dosage regimens commonly used in clinical practice may not be sufficient ...
Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective
(Elsevier, 2020-04)
Objectives: The aim of this study was to assess the influence of renal function, in particular the presence of augmented renal clearance (ARC), on the pharmacokinetics of linezolid in critically ill patients. The effect ...