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Design and evaluation of nucleic-acid based medicinal products to address corneal inflammation by gene therapy
(2022-03-04)
La suplementación génica consiste en la administración de ácidos nucleicos (ADN o ARNm) para inducir la producción de una proteína terapéutica. En la actualidad, el uso del ARNm se ha extendido debido su alta eficacia, ...
Resistencia a antibióticos en dos Unidades de Medicina Intensiva de un hospital terciario: efecto de la descontaminación digestiva selectiva.
(2023-01-27)
La descontaminación digestiva selectiva (DDS) es una estrategia profiláctica basada en la administración de antibióticos tópicos no absorbibles en la mucosa oral y en el tracto gastrointestinal y de un antibiótico de amplio ...
Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering
(Elsevier, 2022-07-25)
Bone tissue engineering has come on the scene to overcome the difficulties of the current treatment strategies. By combining biomaterials, active agents and growth factors, cells and nanomaterials, tissue engineering makes ...
Nanoindartutako 3D biosistemen diseinua, fabrikazioa eta karakterizazioa, hezur-ehunaren ingeniaritzan aplikatzeko
(2023-11-30)
This doctoral thesis focuses on the design, fabrication and subsequent characterization of 3D systems that can be used to restore bone lesions. For this purpose, the principles of bone tissue engineering are applied to ...
Relationship between the dynamics of volatile aroma compounds and microbial succession during the ripening of raw ewe milk-derived Idiazabal cheese
(Elsevier, 2023)
Cheese microbiota contributes to various biochemical processes that lead to the formation of volatile compounds and the development of flavour during ripening. Nonetheless, the role of these microorganisms in volatile aroma ...
Elucidating the combined effect of sample preparation and solid-phase microextraction conditions on the volatile composition of cooked meat analyzed by capillary gas chromatography coupled with mass spectrometry
(Elsevier, 2021-08)
Solid-phase microextraction coupled to gas chromatography-mass spectrometry is a common approach to analyze the volatile profile of cooked meat. The present study aims to investigate the combined effect of sample preparation, ...
Involvement of microbiota and short-chain fatty acids on non-alcoholic steatohepatitis when induced by feeding a hypercaloric diet rich in saturated fat and fructose
(Cambridge University Press, 2022-04)
Consumption of high-energy-yielding diets, rich in fructose and lipids, is a factor contributing to the current increase in non-alcoholic fatty liver disease prevalence. Gut microbiota composition and short-chain fatty ...
Lactobacillus rhamnosus GG administration partially prevents diet-induced insulin resistance in rats: a comparison with its heat-inactivated parabiotic
(RSC, 2023-09-02)
Insulin resistance and type 2 diabetes are obesity-related health alterations, featuring an ever-increasing prevalence. Besides inadequate feeding patterns, gut microbiota alterations stand out as potential contributors ...
Effects of Resveratrol Administration in Liver Injury Prevention as Induced by an Obesogenic Diet: Role of Ruminococcaceae
(MDPI, 2022-07-26)
Gut microbiota dysbiosis has been described in several metabolic disruptions, such as non-alcoholic fatty liver disease (NAFLD). Administration of resveratrol has been claimed to elicit benefits against NAFLD along with ...
Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques
(Elsevier, 2021-05)
Tendon injuries are a global health problem that affects millions of people annually. The properties of tendons make their natural rehabilitation a very complex and long-lasting process. Thanks to the development of the ...