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Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations
(Frontiers Media, 2022)
[EN] LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine protease necessary for proper muscle function. Our previous findings show that CAPN3 deficiency leads to reduced ...
SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa
(Nature Publishing Group, 2020-03-27)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and to a wide ...
Errekuperazio funtzionaleko unitate bateko adinduetan minaren, nutrizio egoeraren eta ebaluazio geriatriko integraleko parametroen arteko erlazioa: errehabilitazioaren eraginaren eta gertakarien arrisku faktoreen analisia
(2022-01-27)
Ebidentziaren arabera, errahabilitazio geriatrikoak, ospitalizazio akutua izan duten adinduetan onurak dituela erakutsi du. Hala ere, hobekuntzak aldagarriak izan daitezke pazientearen arabera. Beraz, ezinbestekoa da ...
Determinants of Participation in a Post-Hospitalization Physical Exercise Program for Older Adults
(BioMed Central, 2020-10-16)
Background: Older patients often experience a decline in physical function and cognitive status after hospitalization. Although interventions involving physical exercise are effective in improving functional performance, ...
The L-Alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis
(Wiley, 2020-11)
Background and Aims G protein-coupled receptor (GPR) 55 is a putative cannabinoid receptor, and l-alpha-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis ...
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
(Sage, 2021-09)
Background Polycystic liver diseases (PLDs) are genetic inherited disorders characterized by the progressive growth of numerous intrahepatic biliary cysts, which are the main cause of morbidity. Previous studies revealed ...
Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study
(MDPI, 2020-09-18)
Nutritional status is relevant to functional recovery in patients after an acute process requiring rehabilitation. Nevertheless, little is known about the impact of malnutrition on geriatric rehabilitation. This study aimed ...
Targeting metabolism for resolving Non-Alcoholic Steatohepatitis.
(2020-01-24)
La presente tesis doctoral trata sobre la modulación del metabolismo para el tratamiento de laesteatohepatitis no alcohólica (EHNA). Esta patología se caracteriza por una acumulación de grasa en elhígado que da lugar a ...
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
(Elsevier, 2022-01)
[EN]Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation process, which is essential for autophagy. Whether ATG3 plays a role in lipid metabolism or contributes ...
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
(Nature, 2020-07-03)
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ ...