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Morfinak DNA-ren metilazioan duen eragin epigenetikoaren azterketa, bigarren belaunaldiko sekuentziazio teknikak erabiliz
(2022-06-24)
Zelulen patroi epigenetikoak haien fisiologia zehazten du, eta organismo baten garapenean zehar zelula bakoitzak duen patroi espezifikoak haren diferentziazioa bideratzen du, organismo osoaren garapen egokia bat koordinatuz. ...
Role of transcription factor KLF5 in the etiopathogenesis and chemoresistance of cholangiocarcinoma: novel diagnostic, prognostic, and therapeutic strategy.
(2023-02-24)
El colangiocarcinoma (CCA) es un cáncer biliar raro y heterogéneo, con una incidencia y mortalidad creciente. En este estudio planteamos la hipótesis de que el factor de transcripción KLF5 actúa como oncogén en el CCA, por ...
Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina
(Elsevier, 2023-05)
Nanodiamonds were combined with niosome, and resulting formulations were named as nanodiasomes, which were evaluated in terms of physicochemical features, cellular internalization, cell viability and transfection efficiency ...
Desajuste emocional y calidad de vida en infertilidad: fecundación in vitro estándar (FIV) vs. maduración in vitro de ovocitos (MIV)
(2023-05-02)
Las mujeres que se someten a técnicas de reproducción asistida (TRA) con frecuencia experimentan un impacto negativo en su calidad de vida y desajuste emocional ante el tratamiento, sin embargo, el efecto de cada una de ...
Biomarker Discovery and Novel Therapies Using Micro-RNAs: deeper insights into liver physiopathology
(2023-07-14)
La enfermedad hepática crónica hace referencia a un amplio espectro de patologías hepáticas lenta progresión, pero potencialmente mortales. A pesar de los avances en diagnóstico y tratamiento, el estilo de vida sedentario, ...
Adaptaciones cardiovasculares a diferentes volúmenes de ejercicio aeróbico interválico de alta intensidad en pacientes tras infarto agudo de miocardio: Estudio INTERFARCT
(2023-07-03)
Estudio que evaluar las adaptaciones cardiovasculares centrales (remodelado ventricular) y periféricas(función endotelial y lípidos plasmáticos) a diferentes programas supervisados de ejercicio aeróbico interválico de alta ...
Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity
(MDPI, 2022-10-10)
E2F1/E2F2 expression correlates with malignancy in prostate cancer (PCa), but its functional significance remains unresolved. To define the mechanisms governed by E2F in PCa, we analyzed the contribution of E2F target genes ...
Acoustophoretic trapping of particles by bubbles in microfluidics
(Frontiers Media, 2023-01)
We present in this paper a simple method to produce strategic acoustic particle capture sites in microfluidic channels in a controlled way. Air bubbles are intermittently injected into a micro-capillary with rectangular ...
Nonionic Surfactants can Modify the Thermal Stability of Globular and Membrane Proteins Interfering with the Thermal Proteome Profiling Principles to Identify Protein Targets
(American Chemical Society, 2023-02)
The membrane proteins are essential targets for understanding cellular function. The unbiased identification of membrane protein targets is still the bottleneck for a system-level understanding of cellular response to ...
Self-assembled three-dimensional hydrogels based on graphene derivatives and cerium oxide nanoparticles: scaffolds for co-culture of oligodendrocytes and neurons derived from neural stem cells
(American Chemical Society, 2023-03)
Stem cell-based therapies have shown promising results for the regeneration of the nervous system. However, the survival and integration of the stem cells in the neural circuitry is suboptimal and might compromise the ...