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Clinical progress in MSC-based therapies for the management of severe COVID-19.
(Elsevier, 2022-12)
Considering the high impact that severe Coronavirus disease 2019 (COVID-19) cases still pose on public health and their complex pharmacological management, the search for new therapeutic alternatives is essential. Mesenchymal ...
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis
(Elsevier, 2021-06-18)
[EN] Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver
fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic ...
FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted
(Elsevier, 2021-04-20)
[EN] Background & Aims: Cholangiocarcinoma (CCA) is a neoplasia of
the biliary tract driven by genetic, epigenetic and transcriptional
mechanisms. Herein, we investigated the role of the transcription
factor FOSL1, as ...
Athletic Clubeko jokalarien lesioak: hazkundea eta heltzea arrisku faktore potentzial gisa.
(2022-12-14)
Los objetivos de esta tesis fueron (1) describir la epidemiología de los equipos del Athletic Club, (2) analizar el crecimiento y maduración como factores de riesgo y (3) comparar los métodos para estimar el estado madurativo. ...
The role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: new potential therapeutic target
(2021-01-29)
Las modificaciones post-traduccionales son mecanismos esenciales para la modulación de respuestas celulares a diversos estímulos. La relevancia de la NEDDilación de proteínas en particular se ha demostrado en distintas ...
Delta and kappa opioid receptors in human endometrium during the menstrual cycle: Expression and localization
(Elsevier, 2023-04)
Objective
Endogenous opioid peptides were reported to be involved in the regulation of reproductive physiology and their precursors and receptors were described in many of the male and female reproductive tissues. Mu ...
Identification of germline cancer predisposition variants in pediatric sarcoma patients from somatic tumor testing
(Nature, 2023-02)
Genetic predisposition is an important risk factor for cancer in children and adolescents but detailed associations of individual genetic mutations to childhood cancer are still under intense investigation. Among pediatric ...
Using the Synergy between HPLC-MS and MALDI-MS Imaging to Explore the Lipidomics of Clear Cell Renal Cell Carcinoma
(American Chemical Society, 2023-01)
Lipid imaging mass spectrometry (LIMS) has been tested in several pathological contexts, demonstrating its ability to segregate and isolate lipid signatures in complex tissues, thanks to the technique’s spatial resolution. ...
Aproximación diagnóstica a las hipoacusias neurosensoriales no sindrómicas de origen genético mediante secuenciación de exoma clínico
(2021-03-16)
La hipoacusia (HA) neurosensorial es la alteración neurosensorial más frecuente en la infancia, con una prevalenciade hasta 3-4/1000 en niños, de los cuales aproximadamente la mitad son de origen genético. La HA hereditaria ...
Training cessation and subsequent retraining of a world-class female Olympic sailor after Tokyo 2020: A case study
(Wiley, 2023-02)
Olympic sailing is a complex sport where sailors are required to predict and interpret weather conditions while facing high physical and physiological demands. While it is essential for sailors to develop physical and ...