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Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1
(Public Library Science, 2021-11-10)
[EN]During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the ...
Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart
(MDPI, 2022-05-27)
Metformin is the first choice drug for the treatment of type 2 diabetes due to positive results in reducing hyperglycaemia and insulin resistance. However, diabetic patients have higher risk of ventricular arrhythmia and ...
TensioBot: a chatbot assistant for self-managed in-house blood pressure checking
(Springer, 2021-03-15)
[ES] Tensiobot es un chatbot de apoyo asistencial, cuyo objetivo esayudar a los pacientes a realizar sus mediciones de tensión arterial en domicilio. Nuestros resultados muestran que el cumplimiento del programa de control ...
Una experiencia práctica para el aprendizaje de Fisiología Humana en los grados de Farmacia y Nutrición Humana y Dietética desde la perspectiva de la cognición corporizada.
(Educación Editora, 2023)
Se presentan los resultados de la investigación de un recurso didáctico enfo-cado desde la teoría de la cognición corporizada, implementado en alumnado de los grados en Nutrición Humana y Dietética y en Farmacia de la ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...
Lipid fingerprint-based histology accurately classifies nevus, primary melanoma, and metastatic melanoma samples
(Wiley, 2024-02)
Probably, the most important factor for the survival of a melanoma patient is early detection and precise diagnosis. Although in most cases these tasks are readily carried out by pathologists and dermatologists, there are ...
Insights into the mechanism of action of the chlorophyll derivative 13-2-hydroxypheophytine a on reducing neutral lipid reserves in zebrafish larvae and mice adipocytes
(Elsevier, 2023-12)
Obesity is a worldwide epidemic and natural products may hold promise in its treatment. The chlorophyll derivative 13-2-hydroxypheophytine (hpa) was isolated in a screen with zebrafish larvae to identify lipid reducing ...
What motivates students to pursue a career in gerontological nursing? The cultural adaptation and validation of the Spanish version of the CMGN questionnaire
(Elsevier, 2024-04)
Background
Career motivation toward gerontological nursing (CMGN) has been studied by various authors. It is essential to identify the influencing factors and guarantee that undergraduate nursing degrees provide adequate ...