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Survival of Frail Elderly with Delirium
(MDPI, 2022-02-16)
This study aims to determine when frailty increases the risks of delirium mortality. Hospital patients falling into the elderly frail or pre-frail category were recruited, some without delirium, some with delirium at ...
Effects of Resistance Training Intervention along with Leucine-Enriched Whey Protein Supplementation on Sarcopenia and Frailty in Post-Hospitalized Older Adults: Preliminary Findings of a Randomized Controlled Trial
(MDPI, 2021-12-24)
Resistance training and protein supplementation are expected to exert the greatest effect in counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to be elucidated. The aim of this study ...
Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model
(Academia Brasileira de Ciencias, 2020)
Type 2 diabetes mellitus (T2DM) is associated with an increase of premature appearance of several disorders such as cardiac complications. Thus, we test the hypothesis that a combination of a high fat diet (HFD) and low ...
Physiological adaptation to altitude. Possible therapeutic implications
(2020)
High altitude is characterised by hypoxia; low levels of oxygen in the atmosphere create a deficiency in oxygen reaching the tissues. Hypoxia creates a stress in all aerobic bodies, leading to physiological, metabolic and ...
Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry
(Frontiers Media, 2021-01-13)
The electrophysiological behavior of the zebrafish heart is very similar to that of the human heart. In fact, most of the genes that codify the channels and regulatory proteins required for human cardiac function have their ...
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
(BMJ Publishing Group, 2021-06-07)
[EN] Objective Hepatocellular carcinoma (HCC) is a prevalent
and aggressive cancer usually arising on a background
of chronic liver injury involving inflammatory and hepatic
regenerative processes. The triggering receptor ...
Generation of NKX2.5(GFP) Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
(Frontiers Media, 2022-01)
Direct cardiac reprogramming has emerged as an interesting approach for the treatment and regeneration of damaged hearts through the direct conversion of fibroblasts into cardiomyocytes or cardiovascular progenitors. ...
Antitumoral actions of natural stilbenes derived from Vitis Vinifera.
(2020-09-25)
Grapes and red wine are the main sources of resveratrol, a polyphenol widely known for its beneficial effects on various diseases. However, other parts of the vine (wood, canes and roots) are important and cheap sources ...
Adiponectin, leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
(Frontiers Media, 2021-06-23)
[EN] Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease where liver biopsy remains the gold standard for diagnosis. Here we aimed
to evaluate the role of circulating adiponectin, ...
Efecto de la inhibición del complejo mTOR en la reguación de la corriente hERG
(2022-03-02)
El gen KCNH2 o hERG (human ether-a-go-go related gene) codifica lassubunidades del canal KV11.1, responsable de la corriente rectificadora tardía rápidade potasio, IKr, en humanos que es fundamental para una correcta ...