Search
Now showing items 11-20 of 173
Ascertaining the initiation of epidemic resurgences: an application to the COVID-19 second surges in Europe and the Northeast United States
(The Royal Society, 2021-10-06)
[EN]Assessing a potential resurgence of an epidemic outbreak with certainty is as important as it is challenging. The low number of infectious individuals after a long regression, and the randomness associated with it, ...
Reflections and Insights on the Evolution of the Biological Remediation of Contaminated Soils
(Frontiers Media, 2021-09-16)
The field of soil biological remediation was initially focused on the use of microorganisms. For organic contaminants, biostimulation and bioaugmentation were the strategies of choice. For heavy metals, bioremediation was ...
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
(Elsevier, 2022-01-16)
[EN] Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that ...
Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer's Disease
(Springer, 2020-08-04)
PurposeAmyloid beta (A beta) drives the accumulation of excess Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) at synapses, inducing synaptic depression and perturbing memory. This recruitment of PTEN to ...
Mitochondrial Membrane Tension Governs Fission
(Elsevier, 2021-04-13)
During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide or reverse upon ...
Optimization of the Bioactivation of Isoflavones in Soymilk by Lactic Acid Bacteria
(MDPI, 2021-05-28)
Soybeans and soy-based products contain isoflavones which can be used for nutraceutical and medical applications. In soybeans and in unfermented soy foods, isoflavones are normally present as glycosides. Isoflavone glycosides ...
Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy
(American Chemical Society, 2021-10-27)
[EN]Monitoring dynamic processes in complex cellular environments requires the integration of uniformly distributed detectors within such three-dimensional (3D) networks, to an extent that the sensor could provide real-time ...
Structural Characterization of the ICOS/ICOS-L Immune Complex Reveals High Molecular Mimicry by Therapeutic Antibodies
(Nature, 2020-10-08)
The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a positive co-stimulatory signal to activated T cells upon binding to its ligand (ICOS-L). Dysregulation of this pathway has been ...
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
(American Society of Clinical Investigation, 2022-04-01)
[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...
Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR
(American Society for Biochemistry and Molecular Biology, 2020-07-17)
Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth ...