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Detecting depression in medically ill patients: comparative accuracy of four screening questionnaires and physicians' diagnoses in Spanish population
(2010-10)
Objective: To compare the diagnostic accuracy of four depression screening tools commonly used in patients with medical disorders, relative to a reference diagnostic standard – a structured psychiatric interview.
Methods: ...
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2
(Wiley, 2010-03-10)
BACE2 is homologous to BACE1, a beta-secretase that is involved in the amyloidogenic pathway of amyloid precursor protein (APP), and maps to the Down syndrome critical region of chromosome 21. Alzheimer disease neuropathology ...
Classification of archaeological pieces into their respective stratum by a chemometric model based on the soil concentration of 25 selected elements
(Elsevier, 2010-04-01)
The aim of this work was to demonstrate that an archaeological ceramic piece has remained buried underground in the same stratum for centuries without being removed. For this purpose, a chemometric model based on Principal ...
Engineering DYRK1A over-dosage yields Down syndrome-characteristic cortical splicing aberrations
(Elsevier, 2010-10)
Down syndrome (DS) associates with impaired brain functions, but the underlying mechanism(s) are yet unclear. The "gene dosage" hypothesis predicts that in DS, overexpression of a single gene can impair multiple brain ...
Goizueta Basque
(2010-03-15)
Goizueta is a small town in northwestern Navarre, Spain, bordering Gipuzkoa. According to the most recent official figures, it has slightly over 800 inhabitants, about 95% of whom speak Basque (2001, Instituto de Estadística ...
Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system
(Elsevier, 2010-05-23)
Cell microencapsulation may represent a breakthrough to overcome problems associated with cell therapy. Advances in material biocompatibility and production protocols have put this field close to its clinical application. ...
Ispilu bizidunak gara: Ispilu-neuronek besteen larruan jartzen gaituzte
(Elhuyar, 2010-06)
Imajinatu zirko-ikuskizun bat ikusten ari zarela. Bat-batean, trapezioan dagoen akrobata irristatu egiten da eta oreka galtzen du… bihotza uzkurtu egin zaizu! Eztarrian korapilo bat duzu eta taupadak bizkortu egin zaizkizu. ...
Hemicelluloses obtaining from rapeseed cake residue generated in the biodiesel production process
(2010-03-25)
[EN]The processing of rapeseed oil seeds for biodiesel production generates huge amounts of lignocellulosiccake residue mainly composed by cellulose, hemicelluloses and lignin. In this work, the valorisation ofthese ...
In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model
(Springer, 2010-07-02)
Down syndrome, the most common genetic disorder leading to mental retardation, is caused by the presence of all or part of an extra copy of chromosome 21. At relatively early ages, Down syndrome patients develop progressive ...
Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP
(American Society for Biochemistry and Molecular Biology, Inc, 2010-03-05)
Interleukin-12 (IL-12), p80, and IL-23 are structurally related cytokines sharing a p40 subunit. We have recently demonstrated that celecoxib and its COX-2-independent analogue 4-trifluoromethyl-celecoxib (TFM-C) inhibit ...