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Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia
(Lippincott, Williams & Wilkins, 2013-02)
Objectives
Methotrexate (MTX) is an important component of therapy for pediatric acute lymphoblastic leukemia (ALL). Treatment with MTX often causes toxicity, which can necessitate dose reduction or treatment cessation. ...
Varying climate sensitivity at the drought-linked distribution edge of P. sylvestris and P. nigra.
(Elsevier, 2013-08-23)
Rear edge populations, those residing at the low-latitude margins of species ranges, represent a critical genetic diversity for species conservation, management, and evolutionary potential. The present study analyses ...
Respuestas fisiológicas y biomecánicas al ejercicio en corredores de diferente origen étnico, especialidad y nivel atlético
(2013-01-10)
El objetivo de este estudio fue determinar si la velocidad correspondiente a 4 mmol¿L-1 de lactato (VOBLA) supone la misma intensidad relativa de ejercicio en corredores de diferente origen étnico, especialidad y nivel ...
Student-generated online videos to develop cross-curricular and curricular competencies in Nursing Studies.
(Elsevier, 2013-07-06)
In response to the necessity of implementing innovative strategies and new teaching methodologies for the design of University degrees curricula according to the new educational model put forward by the European Space of ...
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
(2013-06-18)
[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ...
Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes
(Public Library of Science, 2013)
Chromosome territories constitute the most conspicuous feature of nuclear architecture, and they exhibit non-random distribution patterns in the interphase nucleus. We observed that in cell nuclei from humans with Down ...
Steam reforming of raw bio-oil in a fluidized bed reactor with prior separation of pyrolytic lignin
(ACS, 2013-11-11)
The effect operating conditions (temperature, steam/carbon molar ratio and space-velocity) have on the steam reforming of raw bio-oil has been studied in a two-step reaction unit. In the first step (operated at 500 ºC), a ...
A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia
(Springer, 2013-10-23)
Methotrexate (MTX) is an important component of therapy used to treat childhood acute lymphoblastic leukemia (ALL). Two single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T ...
La promoción de inspectores de 1974 celebra sus bodas de plata
(Centro de Recursos, Interpretación y Estudios de la Escuela, 2013)
En septiembre de 1974 tomaron posesión de sus puestos 62 nuevos Inspectores de Enseñanza Primaria, después de superar los seis ejercicios de una larga oposición convocada casi dos años antes. Esta promoción tuvo un carácter ...
Las lecciones ocasionales: una estrategia metodológica al servicio de la escuela primaria en el Nuevo Estado
(Centro de Recursos, Interpretación y Estudios de la Escuela, 2013)
El artículo que presentamos tiene por objeto analizar el contenido de una lección ocasional, recurso metodológico muy utilizado por los maestros1 del Nuevo Estado para adoctrinar a sus alumnos en el acervo de valores y ...