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Now showing items 21-30 of 57
Desarrollo del proceso de producción de una vacuna para el tratamiento de la alergia a gramíneas basada en una proteína recombinante
(2020-10-14)
La alergia al polen (polinosis) es una de las alergias más comunes que afecta hasta a un 20 % de la población europea, siendo los pólenes de gramíneas los principales causantes de polinosis. Para el tratamiento de la ...
MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
(Life Science Alliance, 2020-01)
The contacts between the ER and mitochondria play a key role in cellular functions such as the exchange of lipids and calcium between both organelles, as well as in apoptosis and autophagy signaling. The molecular architecture ...
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
(MDPI, 2020-11-17)
Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) ...
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments
(Cell Press, 2020-08-18)
The contribution of membrane interfacial interactions to recognition of membrane-embedded antigens by antibodies is currently unclear. This report demonstrates the optimization of this type of antibodies via chemical ...
Using a Simple Cellular Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides
(MDPI, 2020-09-01)
The nuclear export receptor CRM1 (XPO1) recognizes and binds specific sequence motifs termed nuclear export signals (NESs) in cargo proteins. About 200 NES motifs have been identified, but over a thousand human proteins ...
Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease
(MDPI, 2020-08-03)
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that develops due to the interaction between genetic and environmental factors. More than 160 loci have been associated ...
Calcium effect on dynamics and stability of KV7.2 channel
(2020-09-29)
La familia Kv7 controla la excitación celular en diferentes tejidos, por lo que es importante investigar su fisiología y fisiopatología. Se relaciona con enfermedades como la epilepsia, encefalopatías, arritmias, diabetes ...
Fluorescence Microscopy of the HIV-1 Envelope
(MDPI, 2020-03-21)
Human immunodeficiency virus (HIV) infection constitutes a major health and social issue worldwide. HIV infects cells by fusing its envelope with the target cell plasma membrane. This process is mediated by the viral Env ...
Medikamentu bioantzekoak: berezko kontzeptuen eta egungo egoeraren berrikuspena
(2020)
[EUS] Lan honetan bioantzekoak aztertu eta osasun profesional zein pazienteek ulertu beharreko oinarrizko kontzeptu eta ideiak azaltzen dira. Horretarako berrikuspen bibliografiko bat egin da gaia jorratzen duten argitalpenak ...
Modulation of the human disaggregase system by Hsc70-DnaJ associations and small ligands
(2020-07-27)
El sistema desagregasa humano, compuesto por representantes de las familias Hsp70 (Hsc70), Hsp40(DnaJA2 y DnaJB1) y Hsp110 (Apg2) lleva a cabo una gran variedad de funciones cuya finalidad comúnes preservar la proteostasis ...