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Identification of a New Cholesterol-Binding Site within the IFN-gamma Receptor that is Required for Signal Transduction
(Wiley, 2022)
[EN] The cytokine interferon-gamma (IFN-gamma) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN-gamma exerts it signaling ...
Super-Resolution Microscopy to Study Interorganelle Contact Sites
(MDPI, 2022-12-05)
Interorganelle membrane contact sites (MCS) are areas of close vicinity between the membranes of two organelles that are maintained by protein tethers. Recently, a significant research effort has been made to study MCS, ...
The role of interactive states of imnune checkpoint regulators in cancer: determined by quantitative imaging
(2022-02-25)
Immune checkpoint blockade therapies have enhanced cancer therapy in lung and renal cancers aswell as melanoma. Most patients are stratified for anti-PD-1 or anti-CTLA-4 treatments based ontheir PD-L1 ligand expression ...
Translational Bioinformatics for Human Reproductive Biology Research: Examples, Opportunities and Challenges for a Future Reproductive Medicine
(MDPI, 2022-12-20)
Since 1978, with the first IVF (in vitro fertilization) baby birth in Manchester (England), more than eight million IVF babies have been born throughout the world, and many new techniques and discoveries have emerged in ...
Fine-tuning of the Hsc70-based Human Protein Disaggregase Machinery by the Distinctive C-terminal Extension of Apg2
(Elsevier, 2022-11)
Apg2, one of the three cytosolic Hsp110 chaperones in humans, supports reactivation of unordered and ordered protein aggregates by Hsc70 (HspA8). Together with DnaJB1, Apg2 serves to nucleate Hsc70 molecules into sites ...
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
(Nature, 2022-11)
Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen ...
Identification of substrates for human deubiquitinating enzymes (DUBs): An up-to-date review and a case study for neurodevelopmental disorders
(Elsevier, 2022-12)
Similar to the reversal of kinase-mediated protein phosphorylation by phosphatases, deubiquitinating enzymes (DUBs) oppose the action of E3 ubiquitin ligases and reverse the ubiquitination of proteins. A total of 99 human ...
Towards a new generation of non-cytotoxic shape memory thermoplastic polyurethanes for biomedical applications
(Elsevier, 2022-12)
In recent decades, the technology of polymeric materials used in biomedical applications has been greatly improved, replacing the metals that had been used until now. This change has not only meant an improvement in the ...
Pathophysiology of Atherosclerosis
(MDPI, 2022-03-20)
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events ...
Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells
(Frontiers Media, 2022)
[EN] Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The risk alleles have ...