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Evaluation of the biophysical performance upon the integration of helper components into cationic niosomes for the treatment of both retinal and brain diseases by genetherapy approach
(2023-06-29)
The integration of novel compounds into formulations may open up new avenues and opportunities for improving the treatment of various diseases using a genetherapytechnique. To this purpose, my thesis aimed to study the ...
Assessment of Different Niosome Formulations for Optogenetic Applications: Morphological and Electrophysiological Effects
(MDPI, 2023-07-01)
Gene therapy and optogenetics are becoming promising tools for treating several nervous system pathologies. Currently, most of these approaches use viral vectors to transport the genetic material inside the cells, but ...
Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses
(Elsevier, 2023-04)
Subunit vaccines typically require co-administration with an adjuvant to elicit protective immunity, adding development hurdles that can impede rapid pandemic responses. To circumvent the need for adjuvant in a severe acute ...
Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
(Baishideng, 2023)
BACKGROUNDDietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic ...
Mesenchymal stromal cells-based sustainable strategies for wound management: form valorized cell delivery systems to cell-free therapies
(2023-04-21)
In this doctoral thesis, we aimed to develop a complete biomaterial, following a circular economy thinking, which can tackle multiple stages of the wound healing process. In this sense, we designed a sponge-like scaffold ...
Zeolites as Ingredients of Medicinal Products
(MDPI, 2023-04-28)
Development of new medicinal products for particular therapeutic treatment or for better manipulations with better quality and less side effects are possible as a result of advanced inorganic and organic materials application, ...
Estudio de efectividad, seguridad y eficiencia de los nuevos anticoagulantes orales en el tratamiento de la fibrilación auricular no valvular en la CAPV mediante un estudio poblacional de seguimiento.
(2023-02-24)
El objetivo de esta tesis es comparar la efectividad, seguridad y eficiencia de los nuevos anticoagulantes orales (dabigatran, apixaban y rivaroxaban- NACO) frente a acenocumarol en los pacientes con fibrilación auricular ...
High resolution and fidelity 3D printing of Laponite and alginate ink hydrogels for tunable biomedical applications
(Elsevier, 2023-06)
The formulation of hydrogels that meet the necessary flow characteristics for their extrusion-based 3D printing while providing good printability, resolution, accuracy and stability, requires long development processes. ...
Tumour-derived extracellular vesicle based vaccines for melanoma treatment
(Springer, 2023-05)
The interest of extracellular vesicles (EVs) in cancer immunotherapy is increasing every day. EVs are lipid bilayer vesicles released by most cells, which contain the molecular signature of their parent cell. Melanoma-derived ...
Vegetable By-Products as Alternative and Sustainable Raw Materials for Ruminant Feeding: Nutritive Evaluation and Their Inclusion in a Novel Ration for Calf Fattening
(MDPI, 2023-04-18)
This research aimed to evaluate the nutritional composition, in vitro digestibility, and gas production kinetics of 15 vegetable by-products generated by the agri-food industry compared with corn silage as a reference raw ...