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A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
(Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ...
Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis
(Nature, 2020-01-15)
The photoacoustic effect is generated when a variable light interacts with a strongly light-absorbing material. In water, it may produce hot bubbles and shock waves that could affect the integrity of nearby cellular ...
The Myth of The Annular Lipids
(MDPI, 2022-10-22)
In the early 1970s, the existence of a “lipid annulus” stably surrounding the individual intrinsic protein molecules was proposed by several authors. They referred to a number of lipid molecules in slow exchange with the ...
Arachidyl Amido Cholanoic Acid Improves Liver Glucose and Lipid Homeostasis in Nonalcoholic Steatohepatitis Via AMPK and mTOR Regulation
(Baishideng, 2020-09-14)
BACKGROUND Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. ...
Birth and Early Steps of the Organization of Biophysics in Spain
(MDPI, 2022-11-19)
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments ...
The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
(MDPI, 2020-02-29)
The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of brain gangliosides) has been assayed by density gradient ...
Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy
(Nature, 2020-10-19)
Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, ...
C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes
(Nature, 2020-08-24)
The biophysical properties of sphingolipids containing lignoceric (C24:0) or nervonic (C24:1) fatty acyl residues have been studied in multicomponent lipid bilayers containing cholesterol (Chol), by means of confocal ...
Lipid Self-Assemblies under the Atomic Force Microscope
(MDPI, 2021-09-18)
Lipid model membranes are important tools in the study of biophysical processes such as lipid self-assembly and lipid–lipid interactions in cell membranes. The use of model systems to adequate and modulate complexity helps ...
CHO/LY-B Cell Growth under Limiting Sphingolipid Supply: Correlation between Lipid Composition and Biophysical Properties of Sphingolipid-Restricted Cell Membranes
(Wiley, 2021-06)
Sphingolipids (SL) are ubiquitous in mammalian cell membranes, yet there is little data on the behavior of cells under SL- restriction conditions. LY- B cells derive from a CHO linein whichserine palmitoyl transferase ...