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Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights
(MDPI, 2020-07-02)
Statins are the gold-standard treatment for the prevention of primary and secondary cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety and relative tolerability of statins, ...
Pathophysiology of Type 2 Diabetes Mellitus
(MDPI, 2020-07-30)
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues ...
Tecnología Nomad: Desarrollo y caracterización de biosensores fluorescentes codificados genéticamente para su aplicación en ensayos celulares dirigidos al cribado a gran escala de ligandos de receptor
(2020-07-21)
Biosensores fluorescentes codificados genéticamente-Cribado de compuestos a gran escala-Receptores acoplados a proteínas G-Ensayos celulares multicolores-Segundos mensajerosLa primera fase del desarrollo de nuevos medicamentos ...
The role of SUMOylation during development
(Portland Press, 2020-04)
During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process ...
Mutation type classification and pathogenicity assignment of sixteen missense variants located in the EGF-precursor homology domain of the LDLR
(Nature, 2020-02-03)
The primary genetic cause of familial hypercholesterolemia (FH) is related to mutations in the LDLR gene encoding the Low-density Lipoprotein Receptor. LDLR structure is organized in 5 different domains, including an ...
Biomolecular Characterization of PCNA interacting proteins.
(2020-07-27)
PCNA (Proliferating Cellular Nuclear Antigen) es la abrazadera que es desliza sobre el ADN necesaria para la replicación del ADN y la respuesta al daño. PCNA interactúa con numerosas proteínas a través de una secuencia ...
Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition
(MDPI, 2020-09-23)
Cardiovascular disease (CVD), the leading cause of mortality worldwide is primarily caused by atherosclerosis, which is promoted by the accumulation of low-density lipoproteins into the intima of large arteries. Multiple ...
BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque
(MDPI, 2020-12-09)
Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing RNA-Seq data from vascular smooth muscle cells (VSMC) extracted from carotid atheroma surgically excised from a group of ...
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA
(National Academy of Sciences, 2020-03-05)
The vast majority of type 1 diabetes (T1D) genetic association signals lie in non-coding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long non-coding RNAs ...
Mechanism for ESCPE-1 mediated membrane remodelling and cargo selection in endosomal
(2020-10-02)
El reciclaje de proteínas es fundamental para mantener la homeostasis celular. Este trabajo se enfoca en el reciclaje de proteínas que llegan a los endosomas. Allí, las proteínas transmembrana (receptores) son recicladas ...