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Mechanisms of MPER helix binding at membrane interfaces and implications for the broad neutralization of HIV by antibodies
(2016-12-16)
En esta tesis se lleva a cabo un estudio detallado de la función que desempeña el lazo CDR-H3 de losanticuerpos anti MPER 4E10 y 10E8 en al unión y neutralización del VIH así como la contribución de launión directa a lípidos ...
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
(Taylor and Francis, 2021-07-05)
Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope ...
Designed metallo-tags for probing natural systems
(2021-11-26)
El objetivo de este trabajo es el diseño y desarrollo de nuevas etiquetas mediadas por proteínas para estudiar sistemas biológicamente relevantes. Específicamente, el proyecto se centra en el diseño de andamios moleculares ...
Atomistic Insights of Calmodulin Gating of Complete Ion Channels
(MDPI, 2020-02-14)
Intracellular calcium is essential for many physiological processes, from neuronal signaling and exocytosis to muscle contraction and bone formation. Ca<sup>2+</sup> signaling from the extracellular medium depends both on ...
Elucidating Angelman syndromes,s molecular mechanisms by identifying the substrates, interactors and counteracting DUBs of UBE3A
(2022-07-11)
Tesi honetan, aurretiaz Drosophila melanogaster eulian eta saguetan identifikatutako UBE3Aren balizko substratuak balioztatu ditugu, horretarako moldatutako purifikazio estrategia bat erabiliz ¿GFP pull-down estrategia¿. ...
The Expanded mtDNA Phylogeny of the Franco-Cantabrian Region Upholds the Pre-Neolithic Genetic Substrate of Basques
(Public Library of Science, 2013-07-03)
The European genetic landscape has been shaped by several human migrations occurred since Paleolithic times. The accumulation of archaeological records and the concordance of different lines of genetic evidence during the ...
Quantitative proteomic analysis of Parkin substrates in Drosophila neurons
(Biomed Central, 2017-04-11)
Background: Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates ...
A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
(MDPI, 2021-05-03)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
The Ubiquitin Ligase Ariadne-1 Regulates Neurotransmitter Release Via Ubiquitination of NSF
(Elsevier, 2021-02-10)
Ariadne-1 (Ari-1) is an E3 ubiquitin-ligase essential for neuronal development, but whose neuronal substrates are yet to be identified. To search for putative Ari-1 substrates, we used an in vivo ubiquitin biotinylation ...
How to Inactivate Human Ubiquitin E3 Ligases by Mutation
(Frontiers Media, 2020-02-04)
E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein. Numerous diseases are caused by defects in the ...