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Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting order-disorder and gel-fluid domains
(Elsevier, 2011-04)
[EN] The binding and early stages of activity of a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa on giant unilamellar vesicles (GUV) have been monitored using fl uorescence confocal microscopy. Both the ...
Accumulated Bending Energy Elicits Neutral Sphingomyelinase Activity in Human Red Blood Cells
(Elservier, 2012-05-02)
[EN] We propose that accumulated membrane bending energy elicits a neutral sphingomyelinase (SMase) activity in human erythrocytes. Membrane bending was achieved by osmotic or chemical processes, and SMase activity was ...
The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes
(Elsevier B.V., 2014-01-24)
The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) is an antitumor drug that regulates membrane lipid composition and structure. An important effect of this drug is the restoration of sphingomyelin (SM) levels in cancer ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives
(2013-06-18)
[EN] Cellular functions are usually associated with the activity of proteins and nucleic acids. Recent studies have shown that lipids modulate the localization and activity of key membrane-associated signal transduction ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
(Elsevier, 2017-06-19)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) ...
Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
(Nature Publishing, 2018-05-10)
The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a sequence of ...
Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...