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Lipid regulation of Atg8 family protein recruitment and membrane modulation of mitophagy and autophagic cell death
(2017-01-20)
Tesi lan honen aurkikuntzek, mitofagian zehar LC3/GABARAP familiako proteinen mitokondrioetarako errekrutatze-prozesuaren mekanismo molekularraren eta Atg8 proteinaren giza ortologoek giza lerro zelular ezberdinetan daukaten ...
Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization
(ASM, 2014)
The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the ...
Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design
(Elsevier, 2014-01-15)
The membrane-proximal external region (MPER) of gp41 harbors the epitope recognized by the broadly neutralizing anti-HIV 2F5 antibody, a research focus in HIV-1 vaccine development. In this work, we analyze the structure ...
The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region
(Elsevier, 2015-03-18)
The membrane-proximal external region (MPER) C-terminal segment and the transmembrane domain (TMD) of gp41 are involved in HIV-1 envelope glycoprotein-mediated fusion and modulation of immune responses during viral infection. ...
The three lives of viral fusion peptides
(Elsevier, 2014-04)
Fusion peptides comprise conserved hydrophobic domains absolutely required for the fusogenic activity of glycoproteins from divergent virus families. After 30 years of intensive research efforts, the structures and functions ...
Molecular Recognition of the Native HIV-1 MPER Revealed by STED Microscopy of Single Virions
(Springer, 2019-01-08)
Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and accessibility, ...
Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface
(Springer Nature, 2016-12-01)
The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and ...
Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids
(Elsevier, 2010-03-17)
The broadly neutralizing anti-HIV-1 2F5 monoclonal antibody recognizes a gp41 epitope proximal to the viral membrane. Potential phospholipid autoreactivity at cell surfaces has raised concerns about the use of this antibody ...
Mechanical and structural studies of internal lipid-containing bacteriophage PRD1.
(2018-06-18)
La protección del genoma viral durante el viaje extracelular es un requisito absoluto para la supervivencia y replicación del virus. Una vez que la partícula viral se une a la célula huésped, puede comenzar la eyección del ...
Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa
(Elsevier, 2019-01-08)
G-protein coupled receptors (GPCRs) belong to the seven transmembrane receptor superfamily that transduce signals via G proteins in response to external stimuli to initiate different intracellular signaling pathways which ...