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Inoculation of Triatoma Virus (Dicistroviridae: Cripavirus) elicits a non-infective immune response in mice
(Biomed Central, 2013-03)
Background: Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, ...
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
(MDPI, 2015-05)
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...
Membrane properties of ceramide: a fluorescence spectroscopic and microscopic study
(2017-02-24)
Las membranas biológicas son complejas estructuras con una base lipídica y cruciales para lasupervivencia y función de las células. La ceramida es un lípido de membrana con unas característicasfísico-químicas singulares, ...
Regulation of inflammatory processes by ceramide kinase and phosphatidylethanolamine N-methyltransferase in lung cells, adipocytes and liver tissue.
(2019-05-31)
Nowadays, around 60% of the world's population dies due to chronic inflammatory conditions, such as chronic respiratory diseases, obesity, fatty liver disease and cancer. All these pathologies are associated to alterations ...
Mecanismos de reconocimiento y control de tráfico endosomal por el complejo retrómero.
(2018-12-10)
El retrómero es un complejo multiproteíco que participa en múltiples etapas del tráfico vesicular, controlando el reciclaje de cargos presentes en los endosomas a la membrana plasmática, la red Trans-Golgi, así como a ...
Mechanical and structural studies of internal lipid-containing bacteriophage PRD1.
(2018-06-18)
La protección del genoma viral durante el viaje extracelular es un requisito absoluto para la supervivencia y replicación del virus. Una vez que la partícula viral se une a la célula huésped, puede comenzar la eyección del ...
Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate
(2014-02-07)
Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any ...
HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
(Public Library Science, 2014-07)
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism ...
Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression
(Taylor & Francis, 2018-05-07)
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have ...
Exploring The Role Of Genome And Structural Ions In Preventing Viral Capsid Collapse During Dehydration
(IOP Publishing, 2018-03-14)
Even though viruses evolve mainly in liquid milieu, their horizontal transmission routes often include episodes of dry environment. Along their life cycle, some insect viruses, such as viruses from the Dicistroviridae ...