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Glia-Retinal Ganglion Cell Interactions ins the Mammalian Retina: A Neuroprotetive Approach.
(2017-07-03)
Las células ganglionares de la retina (RGCs) son las neuronas responsables de la comunicación entre el ojo y el cerebro, y su muerte puede causar una ceguera irreversible, como ocurre en el glaucoma. Las RGCs se encuentran ...
Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients
(Biomed Central, 2015-01-17)
Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral ...
Transcription Factor Binding Site Enrichment Analysis In Co-Expression Modules In Celiac Disease
(MDPI, 2018-05-10)
The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression ...
Role of lipids in HIV-1 pathogenesis. Implications in viral infectivity and development of antiretroviral drugs.
(2019-05-17)
En esta tesis doctoral se ha estudiado el papel de los lípidos en distintos pasos del ciclo infectivo del VIH-1, y su potencial uso para el desarrollo de agentes antiretrovirales. Los resultados de este trabajo demuestran ...
Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition
(Nature Publishing Group, 2019-07-01)
Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could ...
Lipid-Assisted Polymerization of Nucleotides
(MDPI, 2019-11-05)
In addition to being one of the proponents of the "Lipid World hypothesis", David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their 'non-activated', prebiotically ...
PAnalyzer: A software tool for protein inference in shotgun proteomics
(BioMed Central, 2012-11-05)
Background
Protein inference from peptide identifications in shotgun proteomics must deal with ambiguities that arise due to the presence of peptides shared between different proteins, which is common in higher eukaryotes. ...
Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells
(Public Library Science, 2015-10-13)
Background
Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last ...
Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody : Implications for Anti-2F5 Immunogenicity
(Public Library of Science, 2012-12-21)
The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry ...
Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
(MDPI, 2018-09)
We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains ...