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Birth and Early Steps of the Organization of Biophysics in Spain
(MDPI, 2022-11-19)
In the 1960s, Biophysics was an unheard of scientific field in Spain, and even outside Spain, the distinction between Biophysics and Molecular Biology was not clear at the time. This paper describes briefly the developments ...
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease
(Wiley, 2020-07-07)
[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased
in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence
has been associated with age-dependent hepatosteatosis. ...
Development of biotin-based strategies to dissect the ubiquitin code.
(2022-12-15)
La naturaleza dinámica y reversible de las modificaciones post-traduccionales por parte de los miembros de la familia de la ubiquitina plantea importantes desafíos durante su investigación. En esta Tesis presentamos dos ...
Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance
(Wiley, 2020-09-20)
Protein corona formation on the surface of nanoparticles (NPs) is observed in situ by measuring diffusion coefficients of the NPs under the presence of proteins with a F-19 nuclear magnetic resonance (NMR) based methodology. ...
Data on Links Between Structural and Functional Prokaryotic Diversity in Long-Term Sewage Sludge Amended Soil
(Elsevier, 2018-09-12)
The application of sewage sludge to agricultural soil induces co-exposure of prokaryotic populations to antibiotics and heavy metals, thus exerting a selection pressure that may lead to the development of antibiotic ...
Deciphering the recognition features of glycans by human lectins at the molecular level
(2021-06-28)
Carbohydrates are one of the most variable and complex molecules of biological systems. They areusually located at the cell membrane, mainly as glycoconjugates, glycoproteins or glycolipids and play an important role in ...
Dinaminas en la remodelación de la doble membrana mitocondrial: desarrollo de nuevos enfoques experimentales
(2021-07-30)
originan multitud de patologías. El último paso de la división mitocondrial es la fisión de su doble membrana lipídica. En este Tesis se ha desarrollado un modelo in vitro de nanotubos lipídicos que imita el cuello ...
NMR-based metabolomics in precision medicine. Application to metabolic syndrome and COVID-19.
(2023-06-15)
La medicina de precisión debe considerarse como un enfoque innovador de la medicina tradicional ya que se centra en un tratamiento más personalizado de las patologías de los pacientes en función de sus características ...
Metabolic control of prostate cancer aggressiveness by the tumor stroma.
(2023-05-22)
El cáncer de próstata (CaP) es el segundo cáncer con mayor índice de mortalidad en hombres en la actualidad. Estos fallecimientos se deben a la falta de un buen pronóstico que permita anticipar los casos que van a recidivar. ...
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
(Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...