Search
Now showing items 61-70 of 206
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
(Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ...
Determinación estructural de virus con envuelta lipída mediante crio-microscopía electrónica.
(2020-02-10)
Viruses are parasitic biological agents that in the virion state contain differentmorphologies and assembly organisations. In some virions, a lipid membrane of cellularorigin is a structural component of the infectious ...
Searching for biomarkers of non-alcoholic fatty liver disease and metabolic syndrome
(2020-05-29)
El desarrollo de esta tesis doctoral ha aportado luz sobre los mecanismos que subyacen a la enfermedad del hígado graso no alcohólico (NAFLD por sus siglas en inglés), ya que los resultados han revelado la existencia de ...
Lipid-lipid interactions in bilayers containing polar sphingolipids, ceramide and cholesterol.
(2019-04-11)
La presente tesis se ha centrado el estudio de las interacciones lípido-lípido asociadas a la segregación lateral de esfingolipidos y colesterol. Estos estudios se han llevado a cabo utilizando sistemas de membranas modelo ...
A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold
(Public Library Science, 2013-08)
Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types have been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous ...
Ceramide and ceramide 1-phosphate in health and disease
(BioMed Central, 2010-02)
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the ...
Inoculation of Triatoma Virus (Dicistroviridae: Cripavirus) elicits a non-infective immune response in mice
(Biomed Central, 2013-03)
Background: Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, ...
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
(MDPI, 2015-05)
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of ...
Membrane properties of ceramide: a fluorescence spectroscopic and microscopic study
(2017-02-24)
Las membranas biológicas son complejas estructuras con una base lipídica y cruciales para lasupervivencia y función de las células. La ceramida es un lípido de membrana con unas característicasfísico-químicas singulares, ...
Regulation of inflammatory processes by ceramide kinase and phosphatidylethanolamine N-methyltransferase in lung cells, adipocytes and liver tissue.
(2019-05-31)
Nowadays, around 60% of the world's population dies due to chronic inflammatory conditions, such as chronic respiratory diseases, obesity, fatty liver disease and cancer. All these pathologies are associated to alterations ...