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An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
(Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...
Pathological ATAD3 variants and perturbed cholesterol metabolism in human and fly
(2023-06-22)
Among the hundreds of nuclear-encoded components of mitochondria that have been linked to human disease, mutations in the ATAD3 gene cluster have emerged as one of the most frequent in recent years. The ATAD3 locus encodes ...
Co-Existence of blaNDM-1, blaOXA-23, blaOXA-64, blaPER-7 and blaADC-57 in a Clinical Isolate of Acinetobacter baumannii from Alexandria, Egypt
(MDPI, 2023-08-07)
The increasing rates of antimicrobial resistance among carbapenem-resistant Acinetobacter baumannii in the Middle East and North Africa are one of the major concerns for healthcare settings. We characterised the first A. ...
Phosphatidic Acid Stimulates Lung Cancer Cell Migration through Interaction with the LPA1 Receptor and Subsequent Activation of MAP Kinases and STAT3
(MDPI, 2023-06-23)
Phosphatidic acid (PA) is a key bioactive glycerophospholipid that is implicated in the regulation of vital cell functions such as cell growth, differentiation, and migration, and is involved in a variety of pathologic ...
Relationship between the Dynamics of Gross Composition, Free Fatty Acids and Biogenic Amines, and Microbial Shifts during the Ripening of Raw Ewe Milk-Derived Idiazabal Cheese
(MDPI, 2022-11-21)
This study reports for the first time the relationship between bacterial succession, characterized by high-throughput sequencing (sequencing of V3–V4 16S rRNA regions), and the evolution of gross composition, free fatty ...
Identification and functional characterization of LNCRNAS Associated with TYPE 1 Diabetes.
(2023-05-19)
Estudios de asociación de genoma completo han detectado polimorfismos asociados con el riesgo a padecer diabetes de tipo 1 (DM1) en ARN largos no codificantes (lncRNAs). Sin embargo, todavía se desconocen los mecanismos ...
Structural basis of bacterial glyeans biosynthesis and processing: ímpact in human health and disease
(2023-07-03)
El objetivo a largo plazo de nuestro grupo es estudiar a nivel molecular la estructura, la especificidad por sustrato y el mecanismo de acción de diferentes enzimas bacterianas involucradas en el reconocimiento o modificación ...
Age, Origin and Functional Study of the Prevalent LDLR Mutation Causing Familial Hypercholesterolaemia in Gran Canaria
(MDPI, 2023-07-11)
The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most frequent cause of familial hypercholesterolaemia (FH) in Gran Canaria. The aim of this study was to determine the age and origin of this prevalent ...
Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters
(MDPI, 2023-07-06)
The relationship between milk fat intake (because of its high saturated fatty acid content) and the risk of suffering from cardiovascular diseases remains controversial. Thus, Golden Syrian hamsters were fed two types of ...
Total and Free Fatty Acids Analysis in Milk and Dairy Fat
(MDPI, 2019-03-05)
Dairy fat is one of the most complex natural fats because of its fatty acid (FA) composition. Ruminant dairy fat contains more than 400 different FA varying in carbon chain length, and degree, position and configuration ...