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Age, Origin and Functional Study of the Prevalent LDLR Mutation Causing Familial Hypercholesterolaemia in Gran Canaria
(MDPI, 2023-07-11)
The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most frequent cause of familial hypercholesterolaemia (FH) in Gran Canaria. The aim of this study was to determine the age and origin of this prevalent ...
Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters
(MDPI, 2023-07-06)
The relationship between milk fat intake (because of its high saturated fatty acid content) and the risk of suffering from cardiovascular diseases remains controversial. Thus, Golden Syrian hamsters were fed two types of ...
Total and Free Fatty Acids Analysis in Milk and Dairy Fat
(MDPI, 2019-03-05)
Dairy fat is one of the most complex natural fats because of its fatty acid (FA) composition. Ruminant dairy fat contains more than 400 different FA varying in carbon chain length, and degree, position and configuration ...
Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations
(BioMed Central, 2008-06)
Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic ...
Actin- regulated Siglec- 1 nanoclustering influences HIV-1 capture and virus- containing compartment formation in dendritic cells
(eLife Sciences, 2023-03)
The immunoglobulin-like lectin receptor CD169 (Siglec-1) mediates the capture of
HIV- 1 by activated dendritic cells (DCs) through binding to sialylated ligands. These interactions
result in a more efficient virus capture ...
Novel Methodology for the Detection of Enveloped Viruses
(MDPI, 2020-06-15)
Viral infections in humans cause a huge burden in worldwide healthcare that has increased due to the emergence of new pathogenic viruses, such as in the recent Ebola virus (EBOV) outbreaks. Viral particles in body fluids ...
Structural study of flavivirus immunomodulator proteins from AEDES AEGYPTI salivary glands.
(2023-02-23)
Aedes aegypti bacteria-responsive protein 1 (AgBR1) y neutrophil stimulating factor 1 (NeSt1) son dos proteínas salivales del mosquito Aedes aegypti que actúan como potenciadoras de la infección del virus Zika (ZIKV). En ...
Medidas de afinidad de anticuerpos VIH anti-MPER por su epítopo reconstituido en membranas modelo. Correlación con su polirreactividad y potencia de neutralización.
(2023-04-21)
A pesar de décadas de investigación el VIH aún no ha podido ser erradicado. La existencia de anticuerpos ampliamente neutralizantes se presume una herramienta potente para conseguir una cura funcional o como modelos para ...
Molecular and biological consequences of targeting polyamine metabolism in prostate cancer
(2023-03-31)
The study of tumor metabolism has uncovered a new therapeutic window for the treatment of some cancer types. In such paradigm, cell signaling and metabolic reprogramming can act in tandem for the benefit of the cancer cell. ...
Understanding the role of CaMKIIa in Angelman Syndrome by looking at its potential interactors through proximity labelling
(2023-03-22)
El Síndrome de Angelman es una enfermedad rara que se caracteriza por la ausencia de la E3 ligasa de ubicuitina UBE3A en las neuronas. Numerosos datos sugieren una relación entre CAMKII y UBE3A. En esta tesis se emplea el ...