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Multifunctionality of membrane remodeling proteins Reticulon and Dynamin 2
(2021-07-15)
Los procesos de remodelación de membranas, especialmente aquellos en los que la transformación supone un proceso irreversible, como son la fusión y la fisión, son mecanismos vitales de las células eucariotas para su correcto ...
BFL1 Modulates Apoptosis at the Membrane Level through a Bifunctional And Multimodal Mechanism Showing Key Differences With BCLXL
(Springer Nature, 2018-12-18)
BFL1 is a relatively understudied member of the BCL2 protein family which has been implicated in the pathogenesis andchemoresistance of a variety of human cancers, including hematological malignancies and solid tumours. ...
Geometría lipídica en la regulación de las actividades de la dinamina
(2018-12-19)
Las dinaminas clásicas son grandes GTPasas que median la fisión de la membrana durante la endocitosis. Actúan como enzimas mecano-químicas que convierten la energía obtenida de la hidrólisis del GTP en constricción y ...
Dynamic constriction andfission of endoplasmicreticulum membranes by reticulon
(Nature, 2019-11-22)
The endoplasmic reticulum (ER) is a continuous cell-wide membrane network. Network formation has been associated with proteins producing membrane curvature and fusion, such as reticulons and atlastin. Regulated network ...
Delivery of small nucleic acids by conjugation to carbohydrates and lipids as novel research and therapeutic tools
(2014-03-12)
Small nucleic acids present a great potential to silence specific genes or inhibit the biological activity of specific proteins. Unfortunately, their poor cellular accessibility presents a big challenge for developing an ...
Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1
(National Academy of Sciences, 2022-06)
Identification of a New Cholesterol-Binding Site within the IFN-gamma Receptor that is Required for Signal Transduction
(Wiley, 2022)
[EN] The cytokine interferon-gamma (IFN-gamma) is a master regulator of innate and adaptive immunity involved in a broad array of human diseases that range from atherosclerosis to cancer. IFN-gamma exerts it signaling ...
Structure of HIV-1 gp41 with its Membrane Anchors Targeted by Neutralizing Antibodies
(eLife Sciences, 2021-04-19)
The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate ...
Nonlinear material and ionic transport through membrane nanotubes
(Elsevier, 2021-10-01)
Membrane nanotubes (NTs) and their networks play an important role in intracellular membrane transport and intercellular communications. The transport characteristics of the NT lumen resemble those of conventional solid-state ...
Microfluidic chip with pillar array for controlled production and observation of lipid membrane nanotubes
(RSC, 2020-06-29)
Lipid membrane nanotubes (NTs) are a widespread template for in vitro studies of cellular processes happening at high membrane curvature. Traditionally NTs are manufactured one by one, using sophisticated membrane ...