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Structure of HIV-1 gp41 with its Membrane Anchors Targeted by Neutralizing Antibodies
(eLife Sciences, 2021-04-19)
The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate ...
Nonlinear material and ionic transport through membrane nanotubes
(Elsevier, 2021-10-01)
Membrane nanotubes (NTs) and their networks play an important role in intracellular membrane transport and intercellular communications. The transport characteristics of the NT lumen resemble those of conventional solid-state ...
Microfluidic chip with pillar array for controlled production and observation of lipid membrane nanotubes
(RSC, 2020-06-29)
Lipid membrane nanotubes (NTs) are a widespread template for in vitro studies of cellular processes happening at high membrane curvature. Traditionally NTs are manufactured one by one, using sophisticated membrane ...
Development of soft and rigid membrane nanotemplates for the mechanistic analysis of Dynamin I action on curved surfaces
(2015-03-26)
En los últimos años se ha ido desvelando el rol activo de la curvaturade membrana en los procesos de reorganización de membranas celulares. Lamayoría de las membranas celulares presentan una cierta curvatura; dichacurvatura ...
Super-Resolution Microscopy to Study Interorganelle Contact Sites
(MDPI, 2022-12-05)
Interorganelle membrane contact sites (MCS) are areas of close vicinity between the membranes of two organelles that are maintained by protein tethers. Recently, a significant research effort has been made to study MCS, ...
Design and Validation of a Process Based on Cationic Niosomes for Gene Delivery into Novel Urine-Derived Mesenchymal Stem Cells
(MDPI, 2021-05-11)
Background: Mesenchymal stem cells (MSCs) are stem cells present in adult tissues. They can be cultured, have great growth capacity, and can differentiate into several cell types. The isolation of urine-derived mesenchymal ...
An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding of the Kv7.2 Channel
(Springer, 2021-05-21)
BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. ...
The Multifunctional Role of SPANX-A/D Protein Subfamily in the Promotion of Pro-Tumoural Processes in Human Melanoma
(Nature, 2021-02-11)
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes encode a protein family (SPANX-A, -B, -C and -D), whose expression is limited to the testis and spermatozoa in normal tissues and various ...
P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease
(Elsevier, 2023-01)
Laforin and Malin are two proteins that are encoded by the genes EPM2A and EPM2B, respectively. Laforin is a glucan phosphatase and Malin is an E3-ubiquitin ligase, and these two proteins function as a complex. Mutations ...
The role of interactive states of imnune checkpoint regulators in cancer: determined by quantitative imaging
(2022-02-25)
Immune checkpoint blockade therapies have enhanced cancer therapy in lung and renal cancers aswell as melanoma. Most patients are stratified for anti-PD-1 or anti-CTLA-4 treatments based ontheir PD-L1 ligand expression ...