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Cloning, purification and characterization of two components of phenol hydroxylase from Rhodococcus erythropolis UPV-1
(Springer, 2009-09-29)
Phenol hydroxylase that catalyzes the conversion of phenol to catechol in Rhodococcus erythropolis UPV-1 was identified as a two-component flavin-dependent monooxygenase. The two proteins are encoded by the genes pheA1 and ...
Effect of specific amino acid substitutions in the putative fusion peptide of structural glycoprotein E2 on Classical Swine Fever Virus replication
(Elsevier, 2014-05)
E2, along with Erns and E1, is an envelope glycoprotein of Classical Swine Fever Virus (CSFV). E2 is involved in several virus functions: cell attachment, host range susceptibility and virulence in natural hosts. Here we ...
Exploring the impact of transcriptional deregulation of cell communication related genes in prostate cancer
(2023-10-10)
El cáncer de próstata (CaP) es el segundo cáncer más frecuente en los hombres y ocupa el sexto lugar entre las causas de muerte relacionadas con el cáncer en todo el mundo. A pesar de las prometedoras respuestas clínicas ...
Characterization of environment-related endophenotypes in pulmonary hypertension
(2023-03-02)
La hipertensión pulmonar (HP) es una condición compleja caracterizada por un incremento de la presión en las arterias de los pulmones, que puede dañar el lado derecho del corazón. Clásicamente se define por unos valores ...
The importance of an integrated analysis of clinical, molecular, and functional data for the genetic diagnosis of familial hypercholesterolemia
(Nature, 2015-12)
Purpose
Familial hypercholesterolemia (FH) is one of the most common monogenic disorders, and the high concentrations of low-density lipoprotein (LDL) cholesterol presented since birth confers on these patients an increased ...
The allosteric control mechanisms of alpha-glucan biosynthesis in bacteria
(2023-10-03)
{EN]The alpha-glucans, polysaccharides made of repetitive units of glucose, play a role as energy storage, as with intracellular glycogen, or as structural components, as with the capsular alpha-glucans surrounding the ...
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA
(National Academy of Sciences, 2020-03-05)
The vast majority of type 1 diabetes (T1D) genetic association signals lie in non-coding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long non-coding RNAs ...
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells
(Frontiers Media, 2023-02)
IntroductionMost of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long ...
LncRNA ARGI Contributes to Virus-Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN-Stimulated Genes
(Wiley, 2023-09)
Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D-associated single nucleotide polymorphisms (SNPs) are located in non-coding regions of the human genome. ...