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Bioinspired three-dimensional multifunctional systems to enhance the therapeutic potential of mesenchymal stromal cells
(2019-12-16)
Mesenchymal stromal cells (MSCs) present the ability to secrete important immunomodulatory factors, and therefore, hold great potential for the treatment of multiple inflammatory and immune disorders. However, for the ...
Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres
(Nature Publishing, 2019-12-27)
Cell-laden hydrogel microspheres have shown encouraging outcomes in the fields of drug delivery, tissue engineering or regenerative medicine. Beyond the classical single coating with polycations, many other different coating ...
Review of Advanced Hydrogel-Based Cell Encapsulation Systems for Insulin Delivery in Type 1 Diabetes Mellitus
(MDPI, 2019-11-12)
Type 1 Diabetes Mellitus (T1DM) is characterized by the autoimmune destruction of beta-cells in the pancreatic islets. In this regard, islet transplantation aims for the replacement of the damaged beta-cells through minimally ...
Micro-and macroencapsulation technologies for advanced B-cell replacement in type 1 diabetes mellitus.
(2019-11-15)
La presente tesis doctoral está centrada en la mejora de las tecnologías de micro- y macroencapsulación celular basadas en alginato para su aplicación en el trasplante de células ß como tratamiento de la Diabetes Mellitus ...
Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets
(Elsevier, 2019-02-10)
Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty microcapsules, resulting in high therapeutic graft volumes that can enhance the host’s immune ...
Extracellular matrix protein microarray-based biosensor with single cell resolution: Integrin profiling and characterization of cell-biomaterial interactions
(Elsevier, 2019-08-06)
In the search of biomaterials that promote cell adhesion, it is crucial to explore the integrin-substrate dynamic interactions given in a certain cell type to design successful biofunctionalization strategies. Here, we use ...
Tailored gelatin-based three-dimensional sysems for bone tissue engineering.
(2019-12-17)
The current Doctoral Thesis is focused on the development of three-dimensional systems for bone tissue engineering purposes. Gelatin was chosen as the main material to manufacture scaffolds capable for serving as both ...
Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery
(MDPI, 2019-02)
Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their ...
Diastolic Dysfunction and Exercise Capacity in Patients with Metabolic Syndrome and Overweight/Obesity
(Elsevier, 2019-03)
Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 ...
MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing
(MDPI, 2019-04-18)
Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) molecules, short-hairpin RNA (shRNA) is a plasmid-coded ...