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Gluten gabeko dieta: Euskal Autonomia Erkidegoko pertsona zeliakoen dieta ohiturak
(2019-07-15)
Gaixotasun zeliakoa (GZa) oinarri immunologikoa duen patologia bat da, glutena hartzeak sortzen duena genetikoki joera duten pertsonetan. Glutena prolaminen taldeko proteina da, zenbait zerealen hazietan dagoena. Datuen ...
Diseño de un vector no viral basado en nanopartículas lipídicas para el tratamiento de la hepatitis C mediante ARN de interferencia
(2016-05-05)
La hepatitis C sigue siendo hoy en día un problema de salud pública a nivel mundial. Se estima que hay 170 millones de personas infectadas por el virus de la hepatitis C (HCV, del inglés hepatitis C virus) en el mundo, con ...
Activity of Pterostilbene Metabolites against Liver Steatosis in Cultured Hepatocytes
(MDPI, 2020-11-20)
Pterostilbene is a dimethyl ether derivative of resveratrol, less metabolized than its analogue, due to the substitution of two hydroxyl groups with methoxyl groups. Nevertheless, the amounts of pterostilbene phase II ...
Antibioterapia Streptococcus pneumoniae eta Haemophilus influenzae espezieek eragindako infekzio inbadiltzaile eta ez-inbaditzaileetan: analisi farmakozinetiko/farmakodinamiko bidezko ebaluazioa.
(2020-10-30)
En la actualidad, las infecciones causadas por Streptococcus pneumoniae y por Haemophilus influenzae mantienen una alta prevalencia. Las formas de infección invasivas de estas enfermedades suponen cuadros graves como la ...
Pharmacokinetic/Pharmacodynamic Analysis of Tedizolid Phosphate Compared to Linezolid for the Treatment of Infections Caused by Gram-Positive Bacteria
(MDPI, 2021-06-22)
Tedizolid and linezolid have antibacterial activity against the most important acute bacterial skin and skin-structure infection (ABSSSIs) pathogens. The objective of this work was to apply PK/PD analysis to evaluate the ...
Galactomannan-Decorated Lipidic Nanocarrier for Gene Supplementation Therapy in Fabry Disease
(MDPI, 2022)
Gene supplementation therapy with plasmid DNA (pDNA) represents one of the most promising strategies for the treatment of monogenic diseases such as Fabry disease (FD). In the present work, we developed a solid lipid ...
Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
(MDPI, 2022)
The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue ...
Design,optimization and in vivo evaluation of non-viral vectors for gene therapy. Applications in ocular disorders
(2013-09-27)
[EN] Over the past few years and due to biotechnology development, gene therapy has emerged as a promising therapeutic tool because of the use of exogenous nucleic acids as active ingredients. These nucleic acids, i.e. ...
Individual and Joint Effect of Alpha-Tocopherol and Hydroxytyrosol Acetate on the Oxidation of Sunflower Oil Submitted to Oxidative Conditions: A Study by Proton Nuclear Magnetic Resonance
(MDPI, 2022)
[EN] This study tackles the individual and joint effect of alpha-tocopherol and hydroxytyrosol acetate on the oxidation of sunflower oil submitted to accelerated storage conditions at intermediate temperature, in order to ...
Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs
(2013-05-28)
El objetivo de esta tesis ha sido el desarrollo de una formulación basada en NLCs para la administración de fármacos poco solubles, tanto por vía oral como por vía intravenosa. Para ello: 1. Se ha llevado a cabo la evaluación ...