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Metabolic implications and characterization of hepatic extracellular vesicles in drug-induced liver injury
(2015-07-28)
El daño hepático inducido por drogas (DILI) es un grave problema en las sociedadesdesarrolladas, siendo el responsable de más del 50% de los casos de fallo hepático agudo. Unárea de gran interés, tanto en el diagnóstico ...
Procesos microevolutivos en poblaciones de Sudamérica
(2015-07-23)
Se han valorado los efectos del flujo génico y la deriva sobre el patrimonio genético de un grupo de poblaciones humanas de Sudamérica con características diferentes, tanto desde un punto de vista geográfico y ambiental ...
Estudio de la etiología genética de la insuficiencia ovárica primaria (POI): genes FMR1 Y FMR2
(2015-07-10)
La insuficiencia ovárica primaria (POI) es una disfunción ovárica caracterizada por la aparición de menstruaciones irregulares y niveles altos de gonadotropinas antes de los 40 años. Los alelos intermedios (35-54 CGGs) y ...
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
(Biomed Central, 2015-02-06)
Background: In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ...
Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene
(Public Library Science, 2015-07-06)
Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although ...
Regulación de las GTPasas de la familia Ras y la viabilidad de neuronas dopaminérgicas en respuesta a la señalización purinérgica
(2015-07-27)
El ATP es una molécula natural cuya liberación descontrolada puede elevar su concentración extracelular a rango mM y promover la estimulación de receptores purinérgicos. Se sabe que esta estimulación tiene efectos citotóxicos ...
Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation
(Public Library Science, 2015-08-05)
We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate ...
Ancient DNA from South-East Europe Reveals Different Events during Early and Middle Neolithic Influencing the European Genetic Heritage
(Public Library Science, 2015-06-08)
The importance of the process of Neolithization for the genetic make-up of European populations has been hotly debated, with shifting hypotheses from a demic diffusion (DD) to a cultural diffusion (CD) model. In this regard, ...
Detection of Phylogenetically Informative Polymorphisms in the Entire Euchromatic Portion of Human Y Chromosome From a Sardinian Sample
(Biomed Central, 2015-04-30)
BACKGROUND: Next-Generation Sequencing methods have led to a great increase in phylogenetically useful markers within the male specific portion of the Y chromosome, but previous studies have limited themselves to the study ...
New Nuclear SNP Markers Unravel the Genetic Structure and Effective Population Size of Albacore Tuna (Thunnus alalunga)
(Public Library Science, 2015-06-19)
In the present study we have investigated the population genetic structure of albacore (Thunnus alalunga, Bonnaterre 1788) and assessed the loss of genetic diversity, likely due to overfishing, of albacore population in ...