Search
Now showing items 21-30 of 33
Golgi Oncoprotein GOLPH3 Gene Expression is Regulated by Functional E2F and CREB/ATF Promoter Elements
(MDPI, 2019-03-25)
The Golgi organelle duplicates its protein and lipid content to segregate evenly between two daughter cells after mitosis. However, how Golgi biogenesis is regulated during interphase remains largely unknown. Here we show ...
Haplotipos MAPT en homo sapiens
(2019-06-19)
El objetivo principal de este proyecto de tesis ha sido tratar de desentrañar el misterio tras la peculiar distribución de los haplotipos MAPT en el mundo en general y muy en particular en el continente europeo, de donde ...
Environmental factors modulated ancient mitochondrial DnA variability and the prevalence of rheumatic diseases in the Basque country
(Nature, 2019-12-31)
Among the factors that would explain the distribution of mitochondrial lineages in Europe, climate and diseases may have played an important role. A possible explanation lies in the nature of the mitochondrion, in which ...
A Novel Transcriptome-Derived SNPs Array for Tench (Tinca Tinca L.)
(Public Library Science, 2019-03-19)
Tench (Tinca tinca L.) has great economic potential due to its high rate of fecundity and long-life span. Population genetic studies based on allozymes, microsatellites, PCR-RFLP and sequence analysis of genes and DNA ...
Hygroregulation, a key ability for eusocial insects: Native Western European honeybees as a case study
(Public Library Science, 2019-02-08)
Sociality has brought many advantages to various hymenoptera species, including their ability of regulating physical factors in their nest (e.g., temperature). Although less studied, humidity is known to be important for ...
Does neutral red suit the requirements of being a reliable indicator in clearance rate measurements of suspension-feeding bivalves? An empirical refutation
(Elsevier, 2019-07-01)
One basic requirement in the measurements of feeding rates in suspension-feeding bivalves when using clearance methods is that the suspended particles that are used in the determination of these rates must reach size ...
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
(Nature Publishing Group, 2019-12)
N6-methyladenosine (m6A) is the most common and abundant RNA modification. Recent studies have shown its importance in the regulation of several biological processes, including the immune response, and different approaches ...
The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region
(Nature Publishing, 2019-02-04)
The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD ...
Variants in vincristine pharmacodynamic genes involved in neurotoxicity at induction phase in the therapy of pediatric acute lymphoblastic leukemia
(Springer, 2019-02-06)
Vincristine is an important drug of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early ...
Systematic Review of the Potential of MicroRNAs in Diffuse Large B Cell Lymphoma
(MDPI, 2019-01-26)
Diffuse large B cell lymphoma (DLBCL) is the most common subtype of invasive non-Hodgkin's lymphoma (NHL). DLBCL presents with variable backgrounds, which results in heterogeneous outcomes among patients. Although new tools ...