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Sediment toxicity and bioaccumulation assessment in abandoned Copper and Mercury mining areas of the Nalón River basin (Spain)
(Springer, 2014-11-06)
Sediment toxicity and metal bioaccumulation were assessed at sites affected by historical copper (Cu)
and mercury (Hg) mining activities in the Nalón River basin, Asturias, Spain. Toxicity assessment of stream sediments ...
Chromosomes trapped in micronuclei are liable to segregation errors
(Company Biologist LTD, 2018-07-09)
DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis. Here, we ...
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
(Springer Nature Switzerland AG, 2016-12)
The exportin CRM1 binds nuclear export signals (NESs), and mediates active transport of NES-bearing proteins from the nucleus to the cytoplasm. Structural and biochemical analyses have uncovered the molecular mechanisms ...
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
(Public Library of Science, 2015-06-19)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia ...
Genetic Variants and Hamstring Injury in Soccer: An Association and Validation Study
(American College of Sports Medicine, 2018-02)
Purpose: This study aimed to investigate the association of candidate single nucleotide polymorphisms (SNP) with noncontact hamstring muscle injuries in elite soccer players and to create and validate a model to assess the ...
Mutations in the ‘Fingers’ subdomain of the deubiquitinase USP1 modulate its function and activity
(FEBS Press, 2016-01-13)
Ubiquitin-specific protease (USP)1 is a member of the USP family of deubiquitinating enzymes. Efficient USP1 activity requires binding to its cofactor USP1-associated factor 1 (UAF1), and the USP1-UAF1 deubiquitinase complex ...
From classical to nonparametric growth models: Towards comprehensive modelling of mussel growth patterns
(Elsevier, 2017-03-18)
Understanding biological processes, such as growth, is crucial to development management and sustainability plans for bivalve populations. Von Bertalanffy and Gompertz models have been commonly used to fit bivalve growth. ...
Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
(Oxford University Press, 2017-10)
Background: There is evidence that birthweight is positively associated with body mass
index (BMI) in later life, but it remains unclear whether this is explained by genetic factors
or the intrauterine environment. We ...
Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia
(Wiley, 2018-05-29)
Despite intensification of therapy, 20% of children with acute lymphoblastic leukaemia (ALL) relapse (Ceppi et al, 2015). The different response to chemotherapy may be partially explained by inherited genetic variants, ...
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
(eLife Sciences Publications, 2016-12-14)
Human height variation is determined by genetic and environmental factors, but it
remains unclear whether their influences differ across birth-year cohorts. We conducted an
individual-based pooled analysis of 40 twin ...