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Now showing items 61-70 of 102
Global Self-Regulation of the Cellular Metabolic Structure
(Public Library of Science, 2010-03-02)
Background: Different studies have shown that cellular enzymatic activities are able to self-organize spontaneously, forming a metabolic core of reactive processes that remain active under different growth conditions while ...
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
(Public Library Science, 2015-12-15)
Cannabinoid CB1 receptors peripherally modulate energy metabolism. Here, we investigated the role of CB1 receptors in the expression of glucose/pyruvate/tricarboxylic acid (TCA) metabolism in rat abdominal muscle. ...
Cannabis use and involuntary admission may mediate long-term adherence in first-episode psychosis patients: a prospective longitudinal study
(BioMed Central, 2013-12-01)
Background: This study aimed to examine factors associated with treatment adherence in first-episode psychosis (FEP) patients followed up over 8 years, especially involuntary first admission and stopping cannabis use.
Methods: ...
Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History
(Public Library Science, 2016-08-11)
The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression ...
Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis
(BioMed Central, 2013)
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether
Brain ...
Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial
(Biomed Central, 2014-10-27)
Background: The integrated treatment of first episode psychosis has been shown to improve functionality and negative symptoms in previous studies. In this paper, we describe a study of integrated treatment (individual ...
Online psycho-education to the treatment of bipolar disorder: protocol of a randomized controlled trial
(Biomed Central, 2016-12-22)
Background: Bipolar disorder patients frequently present recurrent episodes and often experience subsyndromal symptoms, cognitive impairment and difficulties in functioning, with a low quality of life, illness relapses and ...
Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes
(Nature Publishing Group, 2010-07)
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause ...
1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death
(Nature Publishing Group, 2013-01)
1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve ...
Systematic review of pharmacological treatments in fragile X syndrome
(BioMed Central, 2009-10-13)
Background: Fragile X syndrome (FXS) is considered the most common cause of inherited mental retardation. Affected people have mental impairment that can include Attention Deficit and/or Hyperactivity Disorder (ADHD), ...