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Hippocampal Neural Stem Cells: from origin to disease. Postnaltal and on-site generation of adult hippocampal neural stem cells and blocking of the epidermal growth factor receptor to preserve neuroge
(2020-12-15)
En la presente tesis se han analizado por un lado el desarrollo, formación y establecimiento de las células madre neurales adultas del hipocampo en la zona subgranular del giro dentado, y por otro la respuesta de ésta ...
Essential Omega-3 Fatty Acids Tune Microglial Phagocytosis of Synaptic Elements in the Mouse Developing Brain
(Nature, 2020-11-30)
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary ...
Dermic-derived fibroblasts for the study of amyotrophic lateral sclerosis
(Wolters Kluwer - Medknow, 2020-11)
Percepciones y vivencias de escolares de 7 a 8 años del País Vasco durante la alerta sanitaria COVID-19
(2020-01)
Objective: To explore the experiences of schoolchildren in an exceptional health alert situation in which strict confinement measures have been applied to the population.Method: Qualitative exploratory study through the ...
Variations of telencephalic development that paved the way for neocortical evolution
(Elsevier, 2020-11)
Charles Darwin stated, "community in embryonic structure reveals community of descent". Thus, to understand how the neocortex emerged during mammalian evolution we need to understand the evolution of the development of the ...
A deep intronic splice variant advises reexamination of presumably dominant SPG7 Cases
(Wiley, 2020-01)
Objective To identify causative mutations in a patient affected by ataxia and spastic paraplegia. Methods Whole-exome sequencing (WES) and whole-genome sequencing (WGS) were performed using patient's DNA sample. RT-PCR and ...
Characterization of blood markers and their implication in human aging.
(2020-01-13)
Aging is a universal, complex and heterogeneous process. In the last decades, an overall improvement in the quality of life and consequent increase in life expectancy has been achieved. In contrast, the disability-free ...
Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
(Frontiers Media, 2020-07-21)
Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity. Thus, severe ...
Never-resting microglia: physiological roles in the healthy brain and pathological implications
(Frontiers Research Foundation, 2014-08-15)
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a ...
Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes
(BioMed Central, 2012-03-10)
Background: Few studies have analyzed predictors of length of stay (LOS) in patients admitted due to acute bipolar manic episodes. The purpose of the present study was to estimate LOS and to determine the potential ...