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Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
(Wiley, 2019-05-28)
Background Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers ...
Desarrollo de un nuevo sistema de cribado masivo basado en la propagación in vitro de priones recombinantes infecciosos para la detección de compuestos con actividad anti-priónica.
(2018-10-29)
Las Encefalopatías Espongiformes Transmisibles (EET) son un grupo de enfermedades neurodegenerativas fatales que se caracterizan por el acúmulo de fibras amiloides de la proteína PrPSc en el sistema nervioso central de los ...
Familial amyloidosis with polyneuropathy type 1 caused by transthyretin mutation Val50Met (Val30Met): 4 cases in a non-endemic area
(Elsevier, 2018-11)
Introduction: Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) typically arises as an autonomic neuropathy primarily affecting small fibres and it occurs in adult patients in their second or third decades ...
Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
(Frontiers Media, 2019-03-26)
Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to ...
Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action
(Elsevier, 2020-06-12)
[EN] Bipolar disorder (BD) is a major healthcare and socio-economic challenge. Despite its substan- tial burden on society, the research activity in BD is much smaller than its economic impact appears to demand. There is ...
Therapeutic potencial of the endocannabinoid system in multiple sclerosis: novel clues from oligodendrocyte CB1 receptors and ABHD6
(2019-03-01)
La esclerosis múltiple es una enfermedad inflamatoria crónica que afecta al sistema nervioso central y se caracteriza por el daño a los oligodendrocitos y la mielina, la infiltración de células inmunes y la degeneración ...
Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease
(Hindawi, 2018)
Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning during development via the complement ...
In vivo PET Imaging of Gliogenesis After Cerebral Ischemia in Rats
(Frontiers Media, 2020-07-30)
In vivopositron emission tomography of neuroinflammation has mainly focused on the evaluation of glial cell activation using radiolabeled ligands. However, the non-invasive imaging of neuroinflammatory cell proliferation ...
CLR01 Protects Dopaminergic Neurons in Vitro and in Mouse Models of Parkinson's Disease
(Nature, 2020-09-28)
Parkinson's disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting ...
Estudio de la uroporfirina I como aproximación terapéutica frente a las encefalopatías espongiformes transmisibles
(2020-11-20)
Las encefalopatías espongiformes transmisibles (EET) son un grupo de enfermedades neurodegenerativas letales causadas por la acumulación de la isoforma malplegada e infectiva (PrPSc) de la proteína priónica celular (PrPC) ...