Search
Now showing items 121-130 of 209
Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations
(Frontiers Media, 2022)
[EN] LGMDR1 is caused by mutations in the CAPN3 gene that encodes calpain 3 (CAPN3), a non-lysosomal cysteine protease necessary for proper muscle function. Our previous findings show that CAPN3 deficiency leads to reduced ...
The Effect of 5-HT1A Receptor Agonists on the Entopeduncular Nucleus is Modified in 6-Hydroxydopamine-Lesioned Rats
(Wiley, 2021-06)
Background and Purpose l-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous ...
Dopaminergic Denervation Impairs Cortical Motor and Associative/Limbic Information Processing Through the Basal Ganglia and its Modulation by the CB1 Receptor
(Academic Press, 2021-01)
The basal ganglia (BG) are involved in cognitive/motivational functions in addition to movement control. Thus, BG segregated circuits, the sensorimotor (SM) and medial prefrontal (mPF) circuits, process different functional ...
A Genotyping Method Combining Primer Competition PCR with HRM Analysis to Identify Point Mutations in Duchenne Animal Models
(Nature, 2020-10-14)
Dystrophin-null sapje zebrafish is an excellent model for better understanding the pathological mechanisms underlying Duchenne muscular dystrophy, and it has recently arisen as a powerful tool for high-throughput screening ...
Communicative and Social Skills among Medical Students in Spain: A Descriptive Analysis
(MDPI, 2020-02-21)
Effective risk communication in public health requires the development of social skills such as active listening and empathy. Communicative and social skills were evaluated in third-year medical students (<i>n</i> = 917) ...
Changes in Day/Night Activity in the 6-OHDA-Induced Experimental Model of Parkinson’s Disease: Exploring Prodromal Biomarkers
(Frontiers Media, 2020-10-14)
The search for experimental models mimicking an early stage of Parkinson's disease (PD) before motor manifestations is fundamental in order to explore early signs and get a better prognosis. Interestingly, our previous ...
Generation of new LGMDR1 models with CRISPR/Cas9 and studies to expand insight into the disease.
(2022-11-25)
La LGMDR1 es la forma más común de las distrofias musculares de cinturas, y está causada por mutaciones en el gen CAPN3. Este gen codifica la proteína calpaína 3, una proteasa no lisosomal que se expresa principalmente en ...
Kirolarien irudi-nahasmenduen azterketa eta dopinaren eragina kirolariengan
(2022-11-14)
Se ha analizado mediante revisión sistemática, el riesgo de desarrollar trastornos de la conducta alimentaria y dismorfia muscular en dos estudios. Tanto el primer estudio como el segundo, revisan estudios de intervención ...
Characterization and pharmacological modulation of calcium handling proteins in Limb-Girdle Muscle Dystrophy type R1
(2021-01-27)
Limb-girdle muscle dystrophy type R1 (LGMDR1) is the most common form of limb-girdle muscle dystrophy, currently with no effective treatment. LGMDR1 is caused by mutations in the CAPN3 gene and is characterized by reduced ...
Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
(Wolters Kluwer Health, 2022-12)
Background:Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol ...