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Mostrando ítems 191-200 de 209
Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
(Wiley, 2021-10)
Background and purpose Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional ...
Estudio de la uroporfirina I como aproximación terapéutica frente a las encefalopatías espongiformes transmisibles
(2020-11-20)
Las encefalopatías espongiformes transmisibles (EET) son un grupo de enfermedades neurodegenerativas letales causadas por la acumulación de la isoforma malplegada e infectiva (PrPSc) de la proteína priónica celular (PrPC) ...
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas
(2020-09-11)
Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo agente causante es una isoforma anormalmente plegada ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...
Quantitative analysis of dysautonomia in patients with autonomic dysreflexia
(Springer, 2021-02-25)
Autonomic dysreflexia (AD) is a life-threatening condition for individuals with cervical or high-thoracic spinal cord injury (SCI). The profile of autonomic dysfunction in AD using validated clinical autonomic tests has ...
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
(Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ...
Autonomic dysfunction is associated with neuropsychological and neuropsychiatric impairment in patients with Lewy body diseases
(Springer-Verlag GmbH Germany, 2020-03-13)
Objective: This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD).
Methods: We included 61 patients [49 with idiopathic Parkinson’s ...
Up-regulation of CB1 Cannabinoid Receptors Located at Glutamatergic Terminals in the Medial Prefrontal Cortex of the Obese Zucker Rat.
(Frontiers Media, 2022-10-18)
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate G i/o ...
Synaptic alterations in the hippocampus of an animal model of progressive parkinsonism and the effect of dopaminergic treatments
(2022-03-04)
This Ph.D. project is focused on the characterization of pathological events in the hippocampus, which could be related to non-motor manifestation in Parkinson's disease such as behavioral and memory impairments. For that ...
Role of MCSF-activated microglia in amyloid-associated pathology
(2022-04-01)
Un evento clave que se desarrolla de forma temprana en la enfermedad de Alzheimer (EA) es el acúmulode las formas oligoméricas del péptido ß-amiloide (oAß) en el cerebro. En este estudio, hemosinvestigado el papel de la ...