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In vivo PET Imaging of Gliogenesis After Cerebral Ischemia in Rats
(Frontiers Media, 2020-07-30)
In vivopositron emission tomography of neuroinflammation has mainly focused on the evaluation of glial cell activation using radiolabeled ligands. However, the non-invasive imaging of neuroinflammatory cell proliferation ...
Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease
(Wiley, 2021-01)
Objective This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD).
Methods Patients with ...
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease
(Frontiers Media, 2022-04-14)
Glial cells are essential to understand Alzheimer's disease (AD) progression, given their role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to manipulate models that allow studying the ...
A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis
(MDPI, 2021-07-06)
Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The ...
CLR01 Protects Dopaminergic Neurons in Vitro and in Mouse Models of Parkinson's Disease
(Nature, 2020-09-28)
Parkinson's disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting ...
Delta(9)-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
(Wiley, 2021-10)
Background and purpose Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional ...
Estudio de la uroporfirina I como aproximación terapéutica frente a las encefalopatías espongiformes transmisibles
(2020-11-20)
Las encefalopatías espongiformes transmisibles (EET) son un grupo de enfermedades neurodegenerativas letales causadas por la acumulación de la isoforma malplegada e infectiva (PrPSc) de la proteína priónica celular (PrPC) ...
Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas
(2020-09-11)
Las Encefalopatías Espongiformes Transmisibles (EET) son un conjunto de desórdenes neurodegenerativos mortales que afectan a varios mamíferos incluidos los humanos, cuyo agente causante es una isoforma anormalmente plegada ...
Characterization of the Isoforms of the Multiple Sclerosis Risk Protein, IL-22 Binding Protein (IL-22BP)
(2021-05-21)
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells (IL-22 binding protein isoform-1 [IL-22BPi1], -2 [IL-22BPi2], and -3 [IL-22BPi3]). Two of these, namely, IL-22BPi2 and IL-22BPi3, are capable of ...
Quantitative analysis of dysautonomia in patients with autonomic dysreflexia
(Springer, 2021-02-25)
Autonomic dysreflexia (AD) is a life-threatening condition for individuals with cervical or high-thoracic spinal cord injury (SCI). The profile of autonomic dysfunction in AD using validated clinical autonomic tests has ...