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Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala
(Frontiers Media, 2019-08-20)
Adult neurogenesis persists in the adult hippocampus due to the presence of multipotent neural stem cells (NSCs). Hippocampal neurogenesis is involved in a range of cognitive functions and is tightly regulated by neuronal ...
Biophysical properties of aqueous humour in ocular pathologies
(2016-05-30)
El limbo corneoescleral contiene estructuras diseñadas para evacuar el humor acuso desde la cámara anterior del ojo hacia la circulación general. Estos elementos se encuentran entre el espolón escleral y la línea de Schwalbe ...
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
(Elsevier Science INC, 2019-10)
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.
Methods: Genome Research at Fundacio ACE (GR@ACE) is a ...
Increased expression of cystine/glutamate antiporter in multiple sclerosis
(BioMed Central, 2011-06-03)
Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which ...
GABAergic and Cortical and Subcortical Glutamatergic Axon Terminals Contain CB1 Cannabinoid Receptors in the Ventromedial Nucleus of the Hypothalamus
(Public Library of Science, 2011-10)
Background: Type-1 cannabinoid receptors (CB1R) are enriched in the hypothalamus, particularly in the ventromedial hypothalamic nucleus (VMH) that participates in homeostatic and behavioral functions including food intake. ...
Visualization by High Resolution Immunoelectron Microscopy of the Transient Receptor Potential Vanilloid-1 at Inhibitory Synapses of the Mouse Dentate Gyrus
(Public Library Science, 2015-03-16)
We have recently shown that the transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel in the peripheral and central nervous system, is localized at postsynaptic sites of the excitatory ...
Study of the long-lasting effects of ethanol consumption during adolescence on cannabinoid type 1 receptor-dependent synaptic transmission and plasticity in dentate gyrus synapses.
(2018-10-17)
El consumo excesivo de alcohol, especialmente durante la adolescencia, es una preocupación generalizada de salud pública. Investigaciones en la última década han puesto de manifiesto que el consumo de etanol (EtOH) y el ...
Effects of acute and chronic restraint stress during adolescence on endocannabinoid-mediated synaptic plasticity in the mouse hippocampal dentate gyrus.
(2019-06-28)
Our society lives embedded in stress. This causes numerous environmental factors that precipitate and exacerbate psychiatric disorders, such as anxiety and depression. In all organisms, stress is recognized as an adaptive ...
Neurotransmitter signaling in the pathophysiology of microglia
(Frontiers Research Foundation, 2013)
Microglial cells are the resident immune cells of the central nervous system. In the resting state, microglia are highly dynamic and control the environment by rapidly extending and retracting motile processes. Microglia ...
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum
(Nature Publishing Group, 2018-04)
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic ...