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The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ’s Neurogenic Response after Neonatal Hypoxia-Ischemia
(MDPI, 2023-06-07)
Neonatal hypoxia-ischemia (HI) often causes hypoxic-ischemic encephalopathy (HIE), a neurological condition that can lead to overall disability in newborns. The only treatment available for affected neonates is therapeutic ...
Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis
(MDPI, 2023-08-18)
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a vital role in maintaining the integrity of myelin, ...
Multimodal imaging of the role of hyperglycemia after experimental aneurysmal subarachnoid haemorrhage
(2023-06-20)
Esta tesis doctoral se ha centrado en el estudio del efecto de la hiperglicemia en un modelo animal de hemorragia subaracnoidea aneurismática mediante técnicas de tomografía por emisión de positrones (PET) y resonancia ...
The role of the brain extracellular space in diffusion and cell signalling
(2023-06-22)
The extracellular space (ECS) is a highly complex space consisting of narrow interconnected channels and reservoirs. The ECS substructures are usually few nanometers wide and consequently, they are very difficult to ...
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
(MDPI, 2021-06-02)
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, ...
Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents
(BMC, 2023-03)
Background
As mental health in adulthood is related to mental status during adolescence, school-based interventions have been proposed to improve resilience. The objective of this study was to build a simulation model ...
The Spanish version of the reflective functioning questionnaire: Validity data in the general population and individuals with personality disorders.
(Public Library Science, 2023-04)
Introduction
Mentalization or reflective functioning (RF) is the capacity to interpret oneself or the others in terms of internal mental states. Its failures have been linked to several mental disorders and interventions ...
Effects of Cannabidiol, Hypothermia, and Their Combination in Newborn Rats with Hypoxic-Ischemic Encephalopathy
(Society for Neuroscience, 2023-04)
Therapeutic hypothermia is well established as a standard treatment for infants with hypoxic-ischemic (HI) encephalopathy but it is only partially effective. The potential for combination treatments to augment hypothermic ...
Identifying alterations in RNA metabolism and translation dynamics of oligodendrocytes in Alzheimer's disease
(2023-04-03)
La degeneración de la mielina y la pérdida de sustancia blanca son eventos tempranos en la enfermedad de Alzheimer (EA) que conducen a déficits cognitivos. Uno de los rasgos distintivos de la EA es la presencia de agregados ...
Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles
(Springer, 2023-01)
Neuropathic pain is associated with abnormal sensations and/or pain induced by non-painful stimuli, i.e., allodynia causing burning or cold sensation, pinching of pins and needles like feeling, numbness, aching or itching. ...