Search
Now showing items 241-250 of 482
Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
(Frontiers Media, 2021-01-29)
Autophagy is a complex process that encompasses the enclosure of cytoplasmic debris or dysfunctional organelles in membranous vesicles, the autophagosomes, for their elimination in the lysosomes. Autophagy is increasingly ...
Differential Exposure to N-Ethyl N-Nitrosourea During Pregnancy is Relevant to the Induction of Glioma and PNSTs in the Brain
(Elsevier, 2021-05-26)
Exposure to N-nitroso compounds (NOCs) during pregnancy has been associated with an increase in brain tumors in the progeny. This study investigated the brain tumorigenic effect of N-ethyl N-nitrosourea (ENU) after ...
Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers
(MDPI, 2022-05-20)
Glial cells participate actively in the early cognitive decline in Alzheimer’s disease (AD) pathology. In fact, recent studies have found molecular and functional abnormalities in astrocytes and microglia in both animal ...
Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
(Frontiers Media, 2022-10)
BackgroundDeficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence ...
Microglial Phagocytosis Dysfunction in the Dentate Gyrus is Related to Local Neuronal Activity in a Genetic Model of Epilepsy
(Wiley, 2020-11)
Objective Microglial phagocytosis of apoptotic cells is an essential component of the brain regenerative response during neurodegeneration. Whereas it is very efficient in physiological conditions, it is impaired in mouse ...
Microglial Corpse Clearance: Lessons From Macrophages
(Frontiers Media, 2020-03-27)
From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. To prevent garbage buildup, the brain is equipped with ...
A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis
(MDPI, 2020-05-21)
NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS). ...
Embodied Pain In Fibromyalgia: Disturbed Somatorepresentations And Increased Plasticity Of The Body Schema
(Public Library Science, 2018-04-06)
Fibromyalgia syndrome (FMS) is a highly prevalent, chronic musculoskeletal condition characterized by widespread pain and evoked pain at tender points. This study evaluated various aspects of body awareness in a sample of ...
The nucleus does not significantly affect the migratory trajectories of amoeba in two-dimensional environments
(Springer Nature, 2019-11-08)
For a wide range of cells, from bacteria to mammals, locomotion movements are a crucial systemic behavior for cellular life. Despite its importance in a plethora of fundamental physiological processes and human pathologies, ...
Evidence of conditioned behavior in amoebae
(Nature, 2019-08-15)
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, ...