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Nuevas estrategias terapéuticas en la Distrofia Miotónica tipo 1 basadas en los mecanismos moleculares del envejecimiento y del cáncer
(2021-01-22)
La Distrofia Miotónica 1 (DM1) es una enfermedad neuromuscular degenerativa multisistémica caracterizada por la expansión del trinucleótido CTG en el gen DMPK. Desde un punto de vista clínico gran parte de los rasgos ...
Cognition, inflammation and related risk factors in suicide attempts
(2022-12-14)
La conducta suicida es un problema de salud global que causa alrededor de 800.000 muertes anuales en el mundo y está asociada a discapacidad y deterioro funcional. De acuerdo al modelo de estrés-diátesis y el enfoque ...
Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?
(BMC, 2022-12)
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by persistent physical and mental fatigue. The post-COVID-19 condition patients refer physical fatigue and cognitive impairment ...
Local diffusion in the extracellular space of the brain
(Elsevier, 2023-02)
The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells. ...
Identificación y caracterización de subgrupos clínicos en el Síndrome de Fatiga Crónica/Encefalomielitis Miálgica. Propuesta de un protocolo para su estudio.
(2022-12-16)
El trabajo se centra en la determinación de subgrupos clínicos en una enfermedad neurológica como el Síndrome de Fatiga Crónica/Encefalomielitis Miálgica (CIE-11: 8E49), y el establecimiento tras análisis de un protocolo ...
Neurocognition and functioning in adolescents at clinical high risk for psychosis
(BMC, 2023-02)
BACKGROUND: Once psychosis has set in, it is difficult for patients to achieve full recovery. Prevention of psychosis and early intervention are promising for improving the outcomes of this disorder. In the last two decades, ...
Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis
(Oxford University Press, 2023-01)
BACKGROUND: Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educational achievements in people at clinical high risk of psychosis (CHR).
METHODS: In ...
Risk of suicide attempt repetition after an index attempt: A systematic review and meta-analysis
(Elsevier, 2023-03)
Objectives
To estimate the risk of suicide attempt repetition among individuals with an index attempt. It also aims to study the role of risk factors and prevention programme in repetition.
Methods
This systematic review ...
Estudio longitudinal y caracterización cognitiva de portadores de la mutación C.709-1G>A en el gen de la Progranulina
(2016-10-28)
La Demencia Frontotemporal (DFT) engloba a un grupo de enfermedades neurodegenerativas clínica y neuropatológicamente heterogéneas, que afectan a los lóbulosfrontales y temporales, y cuyos síntomas principales son alteraciones ...
Regret and therapeutic decisions in multiple sclerosis care: literature review and research protocol
(Frontiers Media, 2021-06-21)
[EN] Background: Decisions based on erroneous assessments may result in unrealistic
patient and family expectations, suboptimal advice, incorrect treatment, or costlymedical
errors. Regret is a common emotion in daily ...