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Modulación de la capacidad de la respuesta reparadora de las células madre mesenquimales derivadas de tejido adiposo.
(2018-07-19)
El aumento de la esperanza de vida y el consecuente envejecimiento de la población ha dado lugar alincremento de la incidencia de diversas enfermedades en cuya fisiopatología interviene un estado inflamatorio crónico y de ...
MGRN1 as a Phenotypic Determinant of Human Melanoma Cells and a Potential Biomarker
(MDPI, 2022-07-26)
Mahogunin Ring Finger 1 (MGRN1), a ubiquitin ligase expressed in melanocytes, interacts with the α melanocyte-stimulating hormone receptor, a well-known melanoma susceptibility gene. Previous studies showed that MGRN1 ...
Conditioned Medium from H2O2-Preconditioned Human Adipose-Derived Stem Cells Ameliorates UVB-Induced Damage to Human Dermal Fibroblasts
(MDPI, 2022-10-11)
Human skin exposure to ultraviolet B (UVB) radiation can result in acute photodamage through oxidative modifications of cellular components and biomolecules involved in the metabolism of dermal cells. Recently, the therapeutic ...
Discoidin Domain Receptor 2 Expression as Worse Prognostic Marker in Invasive Breast Cancer
(Wiley, 2022)
[EN] Discoidin domain receptor 2 (DDR2) is arising as a promising therapeutic target in breast carcinoma (BC). The ability of DDR2 to bind to collagen promotes protumoral responses in cancer cells that influence the tumor ...
Sex-Specific Genetic Effects Associated with Pigmentation, Sensitivity to Sunlight, And Melanoma in a Population of Spanish Origin
(Biomed Central, 2016-03-18)
Background: Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that pigmentation can be modulated by oestrogens and androgens via up-or down-regulation ...
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases
(Wiley, 2019-05-28)
Background Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers ...
Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice
(Biomed Central, 2017-12-06)
Background: Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this ...
Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
(Nature Publishing, 2019-09-11)
The prometastatic stroma generated through tumor cells/host cells interaction is critical for metastatic growth. To elucidate the role of ICAM-1 on the crosstalk between tumor and primary liver sinusoidal endothelial cells ...
Silencing of Sinusoidal DDR1 Reduces Murine Liver Metastasis by Colon Carcinoma
(Nature, 2020-10-27)
Liver metastasis depends on the collagenous microenvironment generated by hepatic sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression, but whether SCs express DDR1 and its implication ...
Innate Lymphoid Cells in the Malignant Melanoma Microenvironment
(MDPI, 2020-10-29)
The role of innate lymphoid cells (ILCs) in cancer progression has been uncovered in recent years. ILCs are classified as Type 1, Type 2, and Type 3 ILCs, which are characterized by the transcription factors necessary for ...