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Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent
(BioMed Central, 2010-05)
Background: Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP ...
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
(Public Library Science, 2016-12-29)
Clear cell renal cell carcinoma (CCRCC) is a heterogeneous and complex disease that frequently develops distant metastases. Fibroblast activation protein (FAP) is a serine peptidase the expression of which in cancer-associated ...
Obesity Parameters, Physical Activity, And Physical Fitness are Correlated With Serum Dipeptidyl Peptidase IV Activity In A Healthy Population
(Elsevier, 2018-05)
Objective: To determine whether obesity, physical fitness, and physical activity parameters are associated with the enzymatic activity of serum dipeptidyl peptidase IV (sDPPIV) in a sample of healthy women and men.
Design ...
Sex differences in the aging pattern of renin–angiotensin system serum peptidases
(Biomed Central, 2017-02-03)
Background: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of ...
Do Thirty-Second Post-activation Potentiation Exercises Improve the 50-m Freestyle Sprint Performance in Adolescent Swimmers?
(Frontiers Media, 2018-10-22)
Objectives: The purpose of the study was to investigate performance, biomechanical, physiological, and psychophysiological effects of a simple and easily organized post-activation potentiation (PAP) re-warm-up performed ...
Plasma rich in growth factors to treat Knee Osteoarthritis
(2017-06-01)
En la tesis titulada Plasma Rich in Growth Factors to treat knee osteoarthritis se exponen 4 trabajosexperimentales basados en el uso del Plasma rico en factores de crecimiento. Los objetivos específicos delos trabajos ...
Macrophage-dependent IL-1 beta production induces cardiac arrhythmias in diabetic mice
(Nature Publishing, 2016-11-24)
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia ...
Kv7 Channels Can Function without Constitutive Calmodulin Tethering
(Public Library of Science, 2011-09-28)
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 ...
Role of SOX17 in the regulation of the biliary phenotype and in cholangiocarcinogenesis
(2016-03-07)
El colangiocarcinoma (CCA) es un grupo heterogéneo de cánceres que afecta a las células de los conductos biliares (i.e. colangiocitos) y que presenta elevada letalidad debido a su diagnóstico tardío y quimioresistencia. ...
Multi-omics integration for biomarker discovery
(2019-12-19)
Los estudios de identificación de nuevos biomarcadores reciben una cantidad notable de financiación, pero su éxito es reducido, con solo un 0.1% de los nuevos biomarcadores identificados llegando a implantarse en la práctica ...