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shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID‑19 case study
(BMC, 2021-10-03)
[EN]Background Quantitative, reverse transcription PCR (qRT-PCR) is currently the gold-standard for SARS-CoV-2 detection and it is also used for detection of other virus. Manual data analysis of a small number of qRT-PCR ...
Elucidation of the molecular and bionergetic mechanisms underlying the resistance to oxidatives stress and the pro-recovery effect of H2O2- preconditioned adipose-derived stem cells
(2020-06-11)
In the field of regenerative medicine, it has been pointed out the relevance of human adipose derived stem cells (hASCs) for cell therapy. They can be easily obtained, have low immunogenicity, and secrete soluble factors ...
Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma
(Spandidos, 2022-05)
[EN] The incidence rates of melanoma have increased steadily in recent decades and nearly 25% of the patients diagnosed with early-stage melanoma will eventually develop metastasis, for which there is currently no fully ...
Nutraceutical Properties of Polyphenols against Liver Diseases
(MDPI, 2020-11-15)
Current food tendencies, suboptimal dietary habits and a sedentary lifestyle are spreading metabolic disorders worldwide. Consequently, the prevalence of liver pathologies is increasing, as it is the main metabolic organ ...
Natural Killer (NK) cells and cancer: nanotechnology-based new methods development for the enhancement of antitumor immunotherapy efficacy
(2022-10-06)
[EU]Jakina denez, NK (ingelesetik ¿natural killer¿) eta T zelulak interleukinekin estimulatzeak, hala nolahobetu egiten ditu haien funtzio efektiboak, minbiziaren erauzteko estrategia izanik. Tesi honetannanoformulazio ...
Bioactive Materials for Next-Generation Dentistry
(MDPI, 2022-12-08)
Teeth were some of the first organs whose function was effectively restored by inert refilling materials that have become widely known to the general public; amalgams, polymeric resin composites, and gutta-percha are some ...
What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors?
(MDPI, 2022-12-19)
Protein convertases (PCs) play a significant role in post-translational procedures by transforming inactive precursor proteins into their active forms. The role of PCs is crucial for cellular homeostasis because they are ...
Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
(Nature, 2023-06)
Originally considered to act as a transcriptional co‑factor, Pirin has recently been reported to play a
role in tumorigenesis and the malignant progression of many tumors. Here, we have analyzed the
diagnostic and ...
Role of RKIP and Pirin in the malignant progression of cutaneous melanoma. New diagnosis and prognosis biomarkers
(2022-09-23)
Melanoma is an extremely lethal skin cancer that arises as a result of the malignant transformation of melanocytes. The incidence of this pathology worldwide has increased in the last 30 years in greater proportion than ...
The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation
(Springer Nature, 2020-10-30)
Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem ...