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Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
(MDPI, 2021-02-01)
Phosphatidic acid (PA) is a bioactive phospholipid capable of regulating key biological functions, including neutrophil respiratory burst, chemotaxis, or cell growth and differentiation. However, the mechanisms whereby PA ...
A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
(MDPI, 2020-11-22)
Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting ...
Click chemistry: an efficient toolbox for the design of chitosand-based hydrogels for biomedicine
(2020-05-28)
The present thesis was focused on the development of new gel-type biomaterials form chitosan withexcellent stimuli-responsive properties using different click reactions. To this end, in the first place,chitosan was endowed ...
Intrinsic kinetics of CO2 methanation on low-loaded Ni/Al2O3 catalyst: Mechanism, model discrimination and parameter estimation
(Elsevier, 2022-03)
The mechanism and kinetic of CO2 methanation reaction of 9.5 % Ni/Al2O3 catalyst is analysed under a wide range of operating conditions. Once the catalyst activity is stabilized, the influence of temperature, total pressure ...
The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance
(Oxford University Press, 2022-08)
Background Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is ...
Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis
(Springer, 2022-05-12)
This study aims to meta-analytically characterize the presence and magnitude of within-group variability across neurocognitive functioning in young people at Clinical High-Risk for psychosis (CHR-P) and comparison groups. ...
Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort
(Elsevier, 2022-06)
[EN] Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common ...
Applicability of LaNiO3-derived catalysts as dual function materials for CO2 capture and in-situ conversion to methane
(Elsevier, 2022-07-15)
The valorisation of CO2 through its capture and in-situ hydrogenation to methane, using dual function materials (DFMs), emerges as promising alternative to reduce CO2 emissions to atmosphere and the global cost of current ...
Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp(3) C-O Bonds in Cyclic Acetals
(American Chemical Society, 2022)
A dual catalytic manifold that enables site-selective functionalization of unactivated sp(3) C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate sigma*-p orbital ...
Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial
(MDPI, 2022)
Despite the negative influence of cannabis use on the development and prognosis of first-episode psychosis (FEP), there is little evidence on effective specific interventions for cannabis use cessation in FEP. The aim of ...