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Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid
(MDPI, 2021-11-30)
Calcium ions (Ca2+) play important and diverse roles in the regulation of autophagy, cell death and differentiation. Here, we investigated the impact of Ca2+ in regulating acute promyelocytic leukemia (APL) cell fate in ...
On the Design, Implementation and Application of Novel Multi-disciplinary Techniques for explaining Artificial Intelligence Models
(2022-01-28)
Artificial Intelligence is a non-stopping field of research that has experienced some incredible growth lastdecades. Some of the reasons for this apparently exponential growth are the improvements incomputational power, ...
‘Digital pills’ for mental diseases: an ethical and social analysis of the issues behind the concept
(Oxford University Press, 2020-07-27)
Recently, the US Food and Drug Administration has given a landmark approval to the very first digital pill with a sensor embedded in the inside. These are complex systems that include a drug and an electronic tracker that ...
Striving for peace: Northern Ireland, from the Good Friday Agreement to Brexit (1998- 2020)
(2020-12-21)
Europe has historically been a battleground for diverse communities, many of which
fighting to achieve some form of power or sovereignty. Medieval battles between
kingdoms lead to wars between empires and lastly to modern ...
Women and judaism: diverse realities between the 19th and 20th centuries
(2020-12-21)
Traditional Jewish communities can be described as androcentric: males have
occupied a central position and they have been the ones to decide women’s place in society. The women archetype in traditional Judaism describes ...
Promoting End-User Involvement in Web-based tasks: a Model-Driven Engineering Approach to Form-filling and User-Acceptance Testing
(2021-02-26)
Many applications which formerly were designed for the desktop have gradually made atransition to the Web. Accordingly, an increasing number of tasks can now be conductedthrough the Web. As a result, opportunities arise ...
Sexual and gender-based crimes in the international criminal court
(2020-06-05)
Tras un amplio repaso de la evolución del manejo de delitos sexuales y de género en el siglo XX y destacar el proceso que conduce a la creación de la Corte Penal Internacional (CPI) y las innovaciones introducidas por el ...
We should not vaccinate the young to protect the old: a response to Giubilini, Savulescu, and Wilkinson.
(Oxford University Press, 2021-05-19)
A recent article by Giubilini, Savulescu, and Wilkinson1 exposes an ethical issue that deserves careful analysis: should we vaccinate children to save the old? The answer provided by the authors is ‘yes’ under the condition ...
Gene editing and disabled people: a response to Felicity Boardman
(Springer-Verlag GmbH Germany, part of Springer Nature, 2020-03-27)
Is the germline gene editing (GEE) of embryos with disabling conditions a moral obligation? According to a recent editorial by F. Broadmann, there are strong reasons to hold the opposite, since “ such a focus on the benefit ...